吉西他滨＋顺铂方案化疗对晚期肺腺癌患者血清内皮抑素及癌胚抗原的影响.pdf

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1、山西医药杂志2013年7月第42卷第7期上半月ShanxiMedJ，July2013，V01．42，No．7the—Fi—rst吉西他滨+Jil~,eft方案化疗对晚期肺腺癌患者血清内皮抑素及癌胚抗原的影响山东省临沂市肿瘤医院(276OOO)魏萍【摘要】目的通过检测晚期肺腺癌患者在应用吉西他滨+顺铂(GP)方案化疗前后血清内皮抑素及血清癌胚抗原(CEA)的水平，观察与化疗疗效的关系；探讨它们与晚期肺腺癌的临床病理特征及预后之间的关系。方法采用双抗体夹心酶联免疫吸附试验(ELISA)定量检测5O例晚期肺腺癌患者化疗前及2周期化疗后血清内皮抑素及CEA水平。结果晚期肺腺癌患

2、者血清内皮抑素及CEA水平显著高于健康人群组(P

3、者34例，中位生存期1O．8个月，低于正常值的患者16例，中位生存期16．4个月，2组差异有统计学意义(P一0．001)。结论血清内皮抑素及CEA在晚期肺腺癌患者中存在高表达；血清内皮抑素及CEA水平与肿瘤分期有关，可反映晚期肺腺癌的恶性侵袭能力；监测血清内皮抑素及CEA水平对判定化疗疗效及预后有一定价值。【关键词】腺癌；癌胚抗原；内皮抑素类；抗肿瘤联合化疗方案；预后TheeffectofGPchemotherapyonserumCEAandendostatininpatientswithadvancedlungadenocarcinomaWEjPing．TumorHo

4、spitalofLinyi，Shandong276000，China[Abstract]ObjectiveBytestingserumCEAandendostatinlevelsbeforeandafterGPchemotherapyofad—vancedlungadenocarcinomapatients，weobservedtheirrelationshipwiththeefficacy，andtherelationshipbe—tweenclinicalpath0physio1ogyofadvancedlungadenocarcinomaandCEA，endost

5、atin，andanalyzedprognosisbe—tweenthetwogroups．MethodsTodetectserumCEAandendostatinlevelsof50advancedlungadenocarcinomapatientsbeforechemotherapyandaftertwocyclesofchemotherapyquantitativelybyELISA．ResultsThisstudyshowedthatserumCEAandserumendostatinlevelofadvancedlungadenocarcinomapatien

6、tswashigherthanthoseinhealthypeoplegroupandtherewassignificantdifference(P

7、P=0．0397)；serumendostatinlevelofllIBstageadvancedlungadenocarcinomapatientswassignificantlyhigherthanthatofIVstagepatients(P一0．0200)．Therewere31easesineffectivegroup(CR+PR)andserumCEAde—creasedsignificantly(P=0．0002)；butserumendostatinlevelsignificantlyincreased(P：0．0359)