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1、血清降钙素原检测在重症乙肝并发自发性细菌性腹膜炎诊断中的意义［摘耍］目的探讨血清降钙素原检测在重症乙肝并发自发性细菌性腹膜炎诊断中的意义。方法整群选取2011年2月一2014年12月在该院就诊的慢性重症乙肝患者142例，根据是否发生自发性细菌性腹膜炎分为并发组(沪61)和对照组5二81),对所有研究对象血清降钙素原、C-反应蛋白水平和白细胞计数进行检测，利用受试者工作特征曲线(R0C曲线)对不同指标诊断效能进行分析。结果并发组组患者降钙素原、C-反应蛋白水平和白细胞计数均高于对照组，差异有统计学意义(P〈0・05)；Pearson相关分析显示，血清降钙索原水平与白细胞计数和C
2、-反应蛋白水平均呈正相关(—0.360和0.851,P<0.001)；降钙素原ROC曲线下面积0.943(95%CT：0.905-0.981),灵敏度86.9%,特异度87.7%；白细胞计数ROC曲线下面积0.765(95%CT：0.687〜0.842),灵敏度88.5%,特异度51.9%；C_反应蛋白ROC曲线下面积0.892(95%CI：0.827〜0.956),灵敏度83.6%,特异度88.9%0结论重症乙肝并发自发性细菌性腹膜炎患者血清降钙索原水平升高，具有较高的诊断效能，可作为患者早期诊断的指标。［关键词］重症乙肝；自发性细菌性腹膜炎；降钙素原；诊断［中图分类号］R
3、7［文献标识码］A［文章编号］1674-0742(2015)08(b)一0017-03[Abstract]ObjectiveToinvestigatethesignificanceofserumprocalcitonindetectioninthediagnosisofseverehepatitisBcomplicatedwithspontaneousbacterialperitonitis・Methods142patientswithChronicseverehepatitisBpatients,whichacceptedinourhospitaJfromFebruary2
4、011toDecember2014,wereselected,andaccordingtotheoccurrenceofspontaneousbacterialperitonitisdividedintothecomplicatedgroup(n二61)andthecontrolgroup(n二81),andthenal1researchobjects，serumprocalcitonin,C-reactiveproteinlevelandwhitebloodcellcountweredetected,indexdiagnosticefficiencywereanalyzed
5、withthereceiveroperatingcharacteristiccurve(ROCcurve)・ResultsConcurrentgrouppatients”serumprocalcitonin,C-reactiveprotein1evelandwhitebloodcel1countwerehigherthanthatofthecontrolgroup,andthedifferencewasstatisticallysignificant(卩〈0.05)•卩earsoncorrelationanalysisshowedthatserumprocalcitoninl
6、evels,whitebloodcellcountandC-reactiveproteinlevelswerepositivelycorrelated(r二0.360and0.851,bothP<0.001)•Forserumprocalcitonin,itsareaundertheROCcurve0.943(95%CI:0.905〜0.981),sensitivity86.9%,specificity87.7%；forwhitebloodcellcount，itsareaundertheROCcurve0.765(95%CI：0.687〜0.842),sensitivity
7、88.5%,specificity51.9%；andforC-reactiveprotein,itsareaundertheROCcurve0.892(95%CT:0.827〜0.956)，sensitivity83.6%,specificityof88.9%.ConclusionThelevelofserumprocalcitoninforthepatientswithseverehepatitisBcomplicatedwithspontaneousbacterialperitonitiswasel
