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时间:2017-12-08
《自体骨髓干细胞移植治疗乙型肝炎肝硬化失代偿期患者41例临床分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中西医结合肝病杂志2010年第20卷第4期·215·doi:10.3969/j.issn.1005-0264.2010.04.008自体骨髓干细胞移植治疗乙型肝炎肝硬化失代偿期患者41例临床分析刘黎周健李多云黄丽雯武汉科技大学附属天佑医院感染科(湖北武汉,430064)摘要目的:观察经肝动脉行自体骨髓干细胞移植治疗乙型肝炎肝硬化失代偿期患者的-临床疗效及安全性。方法:选择乙型肝炎肝硬化失代偿期患者41例,抽取自体骨髓200ml,体外分离纯化骨髓干细胞制成10ml细胞悬液,经肝动脉介入方法移植入肝脏,
2、分别在移植后第2、4、8周复查肝脏功能,观察实验室指标、临床症状及不良反应。结果:移植后第4周和第8周,血清学指标如丙氨酸转氨酶(AIJT)、天门冬氨酸转氨酶(AST)、白蛋白(Alb)、总胆红素(TBil)、凝血酶原时间(Prr)、胆碱酯酶(Che)及甲胎蛋白(AFP)较术前均有明显增高或降低(P3、死亡。4l例患者术中未发生严重并发症,近期无不良反应出现。结论:自体骨髓干细胞移植治疗乙型肝炎肝硬化失代偿期患者临床疗效肯定,安全性良好,可作为中晚期肝硬化患者的临床治疗手段。关键词自体骨髓干细胞;移植;肝硬化,失代偿期Transplantationofautologousbonemarrowstemcellsviahepaticarteryforforty—onepatientswithdecompensatedcirrhosisLIU13,ZHOUJIAN,L,DUO—yuⅣ,eta1.Depa4、rtmentofInfectiousDisease,TianyouHospital,WuhanUnersofScienceandTechnology(WuhanHubei,430064)ChinaAbstractObjective:Toexploretheefectofautologousbonemarrowstemcelltransplantationviahepaticarteryintreat—mentofdecompensatedcirrhosis.Methods:Atotalof200ml5、bonemarrowofeverypatientwasaspiratedfrompostersuperiorspineinasepticconditions.Afterisolationandpurification,thestemcelsweretransplantedintotheliverviahepaticartery.Aftertransplantation,clinicalsymptomsandlaboratorydatawererecordedatthesecond,fourthand6、eighthweek.Results:Fourweeksand8weeksaftertransplantation,setMmparameterssuchasalanineaminotransferase(ALT),aspartateaminotransferase(AST),albumin(Alb),totalbilimbin(TBil),prothrombintime(PT),cholinesterase(Che)andalpha—fetoprotein(AFP)weresignificantl7、yincreasedordecreasecomparedwiththepreoperative(P<0.05);Theefectofautologousbonemar-rowstemcelltransplantationonqualityoflifeinpatientswithdecompensatedhepatitisB:6casesofpleuralefusiondecreased;ascitesdecreasedin13cases;9casesoflowerextremityedemaredu8、ced;appetiteimprovedin12cases,17casesimprovedfa-tigue;bloatingdecreasedin16cases.F0ny—onepatientshadnosevereintraoperativecomplications,noadversereactions.Fourpatientsdiedofcomplicationsduetolivercirrhosis3monthsaftertreatment.Conclusio
3、死亡。4l例患者术中未发生严重并发症,近期无不良反应出现。结论:自体骨髓干细胞移植治疗乙型肝炎肝硬化失代偿期患者临床疗效肯定,安全性良好,可作为中晚期肝硬化患者的临床治疗手段。关键词自体骨髓干细胞;移植;肝硬化,失代偿期Transplantationofautologousbonemarrowstemcellsviahepaticarteryforforty—onepatientswithdecompensatedcirrhosisLIU13,ZHOUJIAN,L,DUO—yuⅣ,eta1.Depa
4、rtmentofInfectiousDisease,TianyouHospital,WuhanUnersofScienceandTechnology(WuhanHubei,430064)ChinaAbstractObjective:Toexploretheefectofautologousbonemarrowstemcelltransplantationviahepaticarteryintreat—mentofdecompensatedcirrhosis.Methods:Atotalof200ml
5、bonemarrowofeverypatientwasaspiratedfrompostersuperiorspineinasepticconditions.Afterisolationandpurification,thestemcelsweretransplantedintotheliverviahepaticartery.Aftertransplantation,clinicalsymptomsandlaboratorydatawererecordedatthesecond,fourthand
6、eighthweek.Results:Fourweeksand8weeksaftertransplantation,setMmparameterssuchasalanineaminotransferase(ALT),aspartateaminotransferase(AST),albumin(Alb),totalbilimbin(TBil),prothrombintime(PT),cholinesterase(Che)andalpha—fetoprotein(AFP)weresignificantl
7、yincreasedordecreasecomparedwiththepreoperative(P<0.05);Theefectofautologousbonemar-rowstemcelltransplantationonqualityoflifeinpatientswithdecompensatedhepatitisB:6casesofpleuralefusiondecreased;ascitesdecreasedin13cases;9casesoflowerextremityedemaredu
8、ced;appetiteimprovedin12cases,17casesimprovedfa-tigue;bloatingdecreasedin16cases.F0ny—onepatientshadnosevereintraoperativecomplications,noadversereactions.Fourpatientsdiedofcomplicationsduetolivercirrhosis3monthsaftertreatment.Conclusio
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