自体骨髓干细胞移植治疗失代偿期肝硬化的临床的的研究 (1)

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1、ClinicalresearchofautologousbonemarrowstemcelltransplantationfortreatmentofdecompensatedincirrhosisMasterdegreecandidate：YueHouSupervisor：Professor‘XiaozhongGuoVice—supervisor：ProfessorXiaozhongGuoMajor：IntemalMedicineAbstractObiective：Tostudytheclinicaleffectofautologousbon

2、emarrowstemcelltransplantationviahepaticarteryintreamtmentofdecompensatedcirrhosis．Methods：Eightypatients、析廿1decompensatedcirrhosiswereincluded．Amongthem,36patientswerefemale，50patientsweremale，theyaged26to75yearsold，meanagewas51士11yearsold，55patientswereposthepatiticcirrhos

3、is，25patientswerealcoholiccirrhosis，1patientwasschistosomiasiscirrhosis，3patientswereautoimmuneliverdisease．and2patientsweredrug．inducedlivercirrhosis．Atotalof180"'200mlbonemarrowwasaspiratedfrompostersuperiorspineinasepticconditions．Afterisolationandpurification，thestemcell

4、sweretransplantedintotheliverviahepaticartery．Aftertransplantation,clinicalsymptomsandsigns，laboratorydataandsideeffectswererecordedatthe2，4and8weeks．Results：Aftertransplantationin2,4and8weeks，levelsofalbuminwasincreased(P

5、otransferasewasdecreased(P

6、g／L．TotalbilirubinlevelWasdecreased，butnosignificantdifferencewasfound．Afterstemeelltransplantation，themajorityofclinicalsymptomswereimproved．In86casesoftransplantpatients，serioussideeffectswerenotfound．Conclusion：Aftertransplantationofautologousbonemarrow,theliverfunctionan

7、dgeneralwell—beingofpatientsweresignificantlyimproved．TKsmethodWassafeandeffectiveinthetreatmentofpatientswithdecopensatedcirrhosis．KeyWords：LivercirrhosisAutologousbonemarrowstemcellsTransplantation2自体骨髓干细胞移植治疗失代偿期肝硬化的临床研究硕士生姓名：侯悦指导教师：郭晓钟教授指导小组：郭晓钟教授专业名称：内科学-^上-·J一刖吾肝硬化是我国一

8、种常见病和多发病，占内科总住院人数的4．3％"14．2％，发病高峰年龄在35"-'48岁，男女比例约为3．6"-'8：1，是危害我国人民健康的一大疾患