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1、封闭抗体疗法治疗免疫性不孕症与习惯性流产效果【关键词】不孕症，免疫;流产，习惯性;抗体,封闭;疗法，免疫［摘要］目的探讨封闭抗体免疫疗法对免疫性不孕症与习惯性流产病人治疗的效果。方法对138例不孕症及习惯性流产病人行封闭抗体免疫治疗2个疗程。采用单向混合淋巴反应封闭试验、单向混合淋巴细胞反应封闭抑制试验、细胞毒试验及封闭抗体流式细胞分析术检测治疗前后病人混合淋巴细胞反应封闭效率（MLR-BE）、抗独特型抗体、细胞毒指数（CI）及抗CD抗原的封闭效率（抗CD-BE）o赛治疗后不孕症及习惯性流产病人的ML
2、R-BE.抗独特型抗体、CI和抗CD-BE均有不同程度的上升，与治疗前相比，差异均有显著性（t=2.32〜38.66,P<0.05、0.01）o治疗2疗程后与治疗1疗程后相比，差异亦有显著性（t=2.15〜12.46,P〈0.05、0.01）。结论封闭抗体免疫疗法治疗免疫性不孕症及习惯性流产具有重要的临床意义和应用价值。[关键词]不孕症，免疫;流产，习惯性;抗体，封闭;疗法，免疫THEEFFICACYOFIMMUNOSUPPRESSIVETHERAPYUSINGBLOCKINGANTIBODIESFO
3、RIMMUNEINFERTILITYANDHABITUALABORTIONSUNLING(CentralLaboratory,QingdaoMunicipalHospital,Qingdao266011,China)[ABSTRACT]ObjectiveToevaluatetheclinicaleffectsofimmunosuppressivetreatmentusingblockingantibodiesonim-muneinfertilityandhabitualabortion.Methods
4、Thisstudywasconductedin138patientswhoweregivenblockingantibodiesfortwocourses・One-waymixedlymphocytereactionblockingtestandcomplement-dependentcytotoxictest,anti-idiotypicanti-bodiestoblockingantibodiesbyone-waymixedlymphocytereactionblockinginhibitingt
5、estwereusedtomonitorblockingantibo-dies,andflowcytometryevaluationofblockingantibodieswasusedtoinvestigateeffectofblockingantibodiesontheCDantigensofTcells・T~Testwasusedforstatisticalanalysis・ResuItsAfteronecourseoftreatment,thelevelsofMLR-BE,theiranti—
6、id—iotypicantibodies,CI,anti-CD4-BE/anti-CD8-BEofimmuneinfertilitygreatlyin-creasedcomparedwiththoseofbeforetreatmentanti-CD3~BE,anti-CD4-BE,anti-CD8~BE,and(t=2.32-38.66;P<0.05,0.01).Aftertwocourses,theMLR-BE,theanti-idiotypicantibodies,CI,anti-CD3-BE,a
7、nti-CD4-BE,anti-CD8~BE,andanti-CD4~BE/anti-CD8~BEofimmuneinfertilitygreatlyin-creasedcomparedwiththoseofbeforetreatment,andthedifferencewassignificantcomparedwiththoseafteronecourseoftreat—ment(t二2.15T2.46;P<0.05,0.01)・ConclusionTheimmunosuppressivether
8、apyusingblockingantibodiesisofgreatclinicalsignificanceandvalueforinfertilityandhabitualabortion・[KEYWORDS]infertility,immune;abortion,habitual;antibodies,blocking;therapy,immunosuppressive临床上许多原因不明确的不孕症以及习惯性流产的病人，经检查抗子宫内膜抗体、抗卵巢抗
