阿托伐他汀强化治疗对老年冠脉综合征患者预后及血清hs-CRP和MMP-9的影响.pdf

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1、实用药物与临床2014年第17卷第3期PracticalPharmacyAndClinicalRemedies，2014，Vo1．17，No．3阿托伐他汀强化治疗对老年冠脉综合征患者预后及血清hs-CRP和MMP-9的影响王伶[摘要]目的探讨阿托伐他汀强化治疗老年冠脉综合征的临床价值。方法将本院诊治的90例冠脉综合征老年患者随机分成2组：实验组45例，采用阿托伐他汀强化方案治疗；对照组45例，采用阿托伐他汀常规方案治疗。观察两组患者的预后情况、血脂水平以及血清炎症因子水平的变化情况。结果用药24周后，实验组

2、患者的心律失常、心力衰竭、心绞痛、心肌梗死等发生率均明显低于对照组(P<0．05)，实验组的TC、TG、LDL—c水平均明显低于对照组(P<0．05)，实验组的HDL—C水平明显高于对照组(P<0．05)；用药4周、24周后，实验组的血清hs—CRP、MMP-9含量均明显低于对照组(P<0．05)。结论阿托伐他汀强化治疗老年冠脉综合征与常规治疗相比，疗效更佳。[关键词]急性冠脉综合征；阿托伐他汀；炎症因子Impactofatorvastatinintensivetreatmentonprognosisand

3、serumhs-CRPandMMP-9ofelderlypatientswithcoronarysyndromeWANGLing(DepartmentofPharmacy，ShaoxingSixthPeopleSHospitalofZh@angProvince，Shaoxing312000，China)[Abstract]ObjectiveToinvestigatetheclinicalvalueofatorvastatinintensivetreatmentonelderlypatientswithcor

4、onarysyndrome．Methods90casesofpatientswithcoronarysyndromeadmittedtoourhospitalwererandom—lydividedintotwogroups，controlgroup(n=45)wastreatedwithatorvastatinconventionairegimen，andtreatmentgroup(n=45)wastreatedwithatorvastatinintensiveregimen．Theprognosis，

5、thechangesoflipidlevelsandserumin—flammatoryfactorlevelsinthe2groupswereobservedandcompared．ResultsTheincidencerateofarrhythmias，heartfailure．angina．myocardialinfarctionafter24weekstreatmentinthetreatmentgroupwassignificantlylowerthanthoseincontrolgroup(P<

6、0．05)；thelipidlevelsofTC，TG，LDL—Cafter24weeks’treatmentinthetreatmentgroupweresignificantlylowerthanthoseofcontrolgroup(P<0．05)；thelevelofHDL—Cafter24weeks’treatmentinthetreatmentgroupweresignificantlyhigherthanthoseofcontrolgroup(尸<0．05)；theserumhs—CRP，MM

7、P一9levelsaf-ter4weeks’and24weeks’treatmentinthetreatmentgroupweresignificantlylowerthanthoseofcontrolgroup(P<0．05)．ConclusionClinicalapplicationofatorvastatinintensivetreatmentonelderlypatientswithcoronarysyndromeismoreeffectivecomparedwithconventionaltrea

8、tment．Keywords：Acutecoronarysyndrome；Atorvastatin；Inflammatoryfactors0引言院治疗的老年ACS患者9O例，所有患者均经心电图、心肌酶谱及冠状动脉造影证实为ACS，排除伴急性冠脉综合征(Acutecoronarysyndrome，t>2级高血压、脑卒中、恶性肿瘤、周围血管梗死性ACS)是由急性心肌缺血、缺氧引起的以冠状动脉疾病、全身免疫系统疾病、严