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时间:2020-04-17
《T细胞斑点试验辅助诊断不同部位肺外结核感染的应用.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中华医院感染学杂志2014年第24卷第17期ChinJNosoeomiolgo1.24No.172014·4415·doi:10.11816/cn.ni.2014—131738论著T细胞斑点试验辅助诊断不同部位肺外结核感染的应用钟一鸣,谷秀梅,刘文恩,李艳明,张运丽(中南大学湘雅医院检验科,湖南长沙410008)摘要:目的探讨T细胞斑点试验(T—SPOT.TB)对不同部位肺外结核的辅助诊断价值。方法选取2011年9月-2012年6月某院诊断为肺外结核的124例患者为观察组,并随机选取同期未合并结核的13
2、0例患者作为对照组,评估T-SPOT.TB诊断不同部位肺外结核的敏感度及两组T—SPOT.TB结果斑点数的差异。结果结果T—SPOT.TB诊断观察组的敏感度为81.5,TST组为65.3,两组比较差异有统计学意义(P3、者的T—SPOT.TB敏感度68.8,免疫正常患者为85.9,两者比较差异均有统计学意义(P4、lOsisindifferentsitesZHONGYi—ming,GUXiu—mei,LIUWen—en,LIYan-ming,ZHANGYun—li(XiangyaHospitalofCentralSouthUniversity,Changsha,Hunan410008,China)Abstract:OBJECTIVEToexplorethevalueofTcellsspottest(T—SP0T.TB)inauxiliarydiagnosisofextrapul~monarytuberculosi5、sindifferentsites.METHODSFromSep2011tOJun2012,totally124patientswithconfirmedextrapulmonarytuberculosiswereassignedastheobservationgroup,meanwhile,130patientswithouttuberculosiswererandomlychosenasthecontrolgroup,thenthesensitivityoftheT—SPOT.TBindiagnos6、isoftheextrapul-monarytuberculosisindifferentsiteswasevaluated,andthedifferenceinthenumberofspotswasobservedandcomparedbetweenthetwogroups.RESULTSThesensitivityoftheT-SPOT.TBindiagnosisoftheextrapulmo~narytuberculosiswas81.5intheobservationgroup,65.3inth7、eTSTgroup,thedifferencebetweenthetwogroupswassignificant(P<0.01);thesensitivityoftheT-SPOT.TBvariedindifferentsitesoftuberculosisinfec—tions,thesensitivityindiagnosisofthelymphnodetuberculosiswas100.0(thehighest),thenolessthantwositesoftuberculosis88.6,t8、heintestinaltuberculosis85.7,thebonejointtuberculosis83.3,thetuberculo—sisperitonitis66.7.ThesensitivityoftheT-SPOT.TBwas88.5%inthepatientswithoutserouseffusions,74.6inthepatientswithseriouseffusions;thesensitivityoftheT-S
3、者的T—SPOT.TB敏感度68.8,免疫正常患者为85.9,两者比较差异均有统计学意义(P4、lOsisindifferentsitesZHONGYi—ming,GUXiu—mei,LIUWen—en,LIYan-ming,ZHANGYun—li(XiangyaHospitalofCentralSouthUniversity,Changsha,Hunan410008,China)Abstract:OBJECTIVEToexplorethevalueofTcellsspottest(T—SP0T.TB)inauxiliarydiagnosisofextrapul~monarytuberculosi5、sindifferentsites.METHODSFromSep2011tOJun2012,totally124patientswithconfirmedextrapulmonarytuberculosiswereassignedastheobservationgroup,meanwhile,130patientswithouttuberculosiswererandomlychosenasthecontrolgroup,thenthesensitivityoftheT—SPOT.TBindiagnos6、isoftheextrapul-monarytuberculosisindifferentsiteswasevaluated,andthedifferenceinthenumberofspotswasobservedandcomparedbetweenthetwogroups.RESULTSThesensitivityoftheT-SPOT.TBindiagnosisoftheextrapulmo~narytuberculosiswas81.5intheobservationgroup,65.3inth7、eTSTgroup,thedifferencebetweenthetwogroupswassignificant(P<0.01);thesensitivityoftheT-SPOT.TBvariedindifferentsitesoftuberculosisinfec—tions,thesensitivityindiagnosisofthelymphnodetuberculosiswas100.0(thehighest),thenolessthantwositesoftuberculosis88.6,t8、heintestinaltuberculosis85.7,thebonejointtuberculosis83.3,thetuberculo—sisperitonitis66.7.ThesensitivityoftheT-SPOT.TBwas88.5%inthepatientswithoutserouseffusions,74.6inthepatientswithseriouseffusions;thesensitivityoftheT-S
4、lOsisindifferentsitesZHONGYi—ming,GUXiu—mei,LIUWen—en,LIYan-ming,ZHANGYun—li(XiangyaHospitalofCentralSouthUniversity,Changsha,Hunan410008,China)Abstract:OBJECTIVEToexplorethevalueofTcellsspottest(T—SP0T.TB)inauxiliarydiagnosisofextrapul~monarytuberculosi
5、sindifferentsites.METHODSFromSep2011tOJun2012,totally124patientswithconfirmedextrapulmonarytuberculosiswereassignedastheobservationgroup,meanwhile,130patientswithouttuberculosiswererandomlychosenasthecontrolgroup,thenthesensitivityoftheT—SPOT.TBindiagnos
6、isoftheextrapul-monarytuberculosisindifferentsiteswasevaluated,andthedifferenceinthenumberofspotswasobservedandcomparedbetweenthetwogroups.RESULTSThesensitivityoftheT-SPOT.TBindiagnosisoftheextrapulmo~narytuberculosiswas81.5intheobservationgroup,65.3inth
7、eTSTgroup,thedifferencebetweenthetwogroupswassignificant(P<0.01);thesensitivityoftheT-SPOT.TBvariedindifferentsitesoftuberculosisinfec—tions,thesensitivityindiagnosisofthelymphnodetuberculosiswas100.0(thehighest),thenolessthantwositesoftuberculosis88.6,t
8、heintestinaltuberculosis85.7,thebonejointtuberculosis83.3,thetuberculo—sisperitonitis66.7.ThesensitivityoftheT-SPOT.TBwas88.5%inthepatientswithoutserouseffusions,74.6inthepatientswithseriouseffusions;thesensitivityoftheT-S
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