[精品]银杏达莫注射液联合雷米普利对2型糖尿病肾病临床疗效观察.doc

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1、银杏达莫注射液联合雷米普利对2型糖尿病肾病临床疗效观察银杏达莫注射液联合雷米普利对2型糖尿病肾病临床疗效观察【中图分类号】R587.2【文献标识码】B【文章编号】1672-3783(2011)08-0445-01【摘耍】目的：通过银杏达莫注射液与雷米普利联合治疗糖尿病肾病前后尿微量白蛋白/肌酹(UAlb/Cre)水平的变化，观察银杏达莫注射液治疗糖尿病肾病的临床疗效。方法：将75例2型糖尿病肾病受试者，随机分为银杏达莫注射液与雷米普利联合治疗组(治疗组)和单用雷米普利治疗(ACEI组)。分别应用雷米普利(2.5mg"5mg/d)加用银杏达莫注射液20ml加入25

2、0ml生理盐水中静脉滴注治疗及单用雷米普利每日2・5mg〜治疗4周。观察治疗前后尿微量白蛋白/肌酹(UAlb/Cre)水平的变化。结果:1.治疗组及ACET组患者治疗后UAlb/Cre等均较治疗前有明显下降(39.37±2.46ug/mgvs69.85±5.04ug/mg;P<0.01；46.88±3.07ug/mgvs71.79±5.64ug/mg;P<0.01)o2・治疗组UAlb/Cre的改善明显优于对照组(39.37+2.46ug/mgvs46.88+3.07ug/mg;p<0.05)o结论:银杏达莫注射液联合雷米普利治疗可明显降低UAlb/Cre,对肾

3、功能的改善优于单用雷米普利治疗。【关键词】糖尿病肾病；尿微量白蛋白；Ginkgobi1obaextractanddipyridamoleinjectioncombinedwithRamiprilintype2diabeticnephropathyClinicalobservationWUYan,YUHe-lin,LTUYang,JTANGLi,CHENCheng,[Abstract]ObjectiveByGinkgobi1obaextractanddipyridamoleinjectionbeforeandafterramipri1treatmentofdiab

4、eticnephropathyurinaryalbumin/creatinine(UA1b/Cre)levelsinobservedginkgobilobaextractanddipyridamoleinjectioninthetreatmentofdiabeticnephropathy.Methods75patientswithtype2diabeticnephropathysubjectswererandomlydividedintotwogingkoinjectioncombinedwithramipriltreatmentgroup(treatmentg

5、roup)andsingletherapywithramipril(ACEIgroup)・Wereramipril(2.5mg、5mg/d)plusaddedgingkoinjection20mland250mlnormalsalineintravenoustreatmentandasingle2.5mg〜5mgdailywithramipriltreatmentfor4weeks・Oftreatment,urinaryalbumin/creatinine(UAlb/Cre)levelchanges・Results1.TreatmentgroupandACEIg

6、rouppatientsaftertreatmentUAlb/Creweresignificantlydecreasedthanbefore(39.37±2.46ug/mgvs69.85±5.04ug/mg;P<0.01；46.88±3.07ug/mgvs71.79+5.64ug/mg;P<0.01).2.ThetreatmentgroupUAlb/Cre(39.37±2.46ug/mgvs46.88±3・07ug/mg;p〈0.05)improvementthanthecontrolgroup・ConclusionGinkgobilobaextractandd

7、ipyridamoleinjectioncombinedwithramipriltreatmentcansignificantlyreduceUAlb/Cre,theimprovementofrenalfunctionbetterthanramiprilinthetreatment・[KeyWords]Diabeticnephropathy;Microalbuminuria糖尿病肾病(diabeticnephropathy,DN)是糖尿病微血管病变最常见的并发症之一，早期诊断及治疗以延缓DN的发生发展是人们关注的热点。近年中医中药研究在糖尿病并发症的领域有一定的

8、进展(r3)o银杏达莫注