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时间:2017-12-07
《^131i治疗graves病疗效的临床因素分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、标记免疫分析与临床2013年12月第20卷第6期3871I治疗Graves病疗效的临床因素分析朱明风,温赤君,钱红,史爱兰,张云秀(上海市第二人民医院,上海200011)摘要:目的探讨”I治疗Graves病患者转归的直接影响因素。方法302例Graves病患者接受”I治疗,治疗前做吸碘试验,治疗前和治疗三年后各抽血一次,检测血清T3、T4、FTr,、Fr4、s_TSH、TRAb、TPOAb。依据治疗三年后甲状腺功能情况分为:复发组、治愈组、甲减组,并对三组患者年龄、性别、治疗剂量、治疗前吸碘率、T3、T4、Fr,、兀、s—TSH、TRAb、TPO
2、Ab等因素进行比较。结果患者性别、治疗前吸碘率、血清1r3、T、fTr、FT、s—TSH比较,各组之间差异无统计学意义(P>0.05);甲减组年龄低于复发组(P<0.05);复发组”I治疗剂量高于治愈组(P<0.05);治愈组TRAb高于甲减组(P<0.05);治疗前血清TPOAb比较,甲减组最高,治愈组次之,复发组最低,三者之间有明显差异(P<0.01)。结论患者年龄、”。I治疗剂量、血清TRAb、TPOAb等因素与Graves病”I治疗后的转归有一定的关系。患者年龄低的容易发生甲减。少数严重的Graves病患者尽管治疗剂量大仍难治愈且易复发。
3、治疗前TRAb低的患者容易发生甲减,TPOAb越高,越易发生甲减。关键词:Graves病;”I;TRAb;TPOAb;甲减中图分类号:R581.3文献标识码:A文章编号:1006—1703(2013)06—0387—03doi:10.11748/bjmy.issn.1006-1703.2013.06.OO6AnalysisofClinicalFactorsfortheEficacyof玎IinTreatingGraves’DiseaseZHUMing—feng,WENChi—jun,QIANHong,SHIAi—lan,ZHANGYun—xiu(
4、Shanghai2People’shospital,Shanghai200011,China)Abstract:ObjectiveFindoutthedirectinfluencingfactorsf0rthetreatmentoftheGraves’diseaseby”I.Method302patientswithGravesdiseaseweretreatedwith”I.AnIodineabsorptiontesthadbeendonebeforethetreatment.Beforeandthreeyearsafterthetreatme
5、nt,patients’differentserumfactorssuchasT3,T4,FT3,FT4,s-TSH,TRAbandTPOAbweredetected.Accordingtotheirthyroidfunctions3yearsaftertreatment,pa—tientsweredividedinto3groupsasfollows:relapsegroup,curedgroupandhypothyroidismgroup.Age,gen-der,therapeuticdose,Iodineabsorptionefficien
6、cy,T3,T4,FT3,丌’4,s—TSH,TRAbandTPOAbwerecorn-paredamongthe3groups.ResultsForfactorsasgender,Iodineabsorptioneficiency,bloodserumsT3,T4,Frr3,FT4ands—TSH,therewerenostatisticaldifferencesamongthe3groups(P>0.05).Ageofhypothyroid—ismgroupwaslowerthanthatofrelapsegroup(P<0.05).Ithe
7、rapeuticdoseofrelapsegroupwashigherthanthatofcuredgroup(P<0.05).TRAbofcuredgroupwashigherthanthatofhypothyroidismgroup(P<0.05).ForserumTPOAbbeforetreatment,hypothyroidismgroupwasthehighest,relapsegroupwasthelowest,whilecuredgroupwasinbetween,therewerestatisticaldifferences(P<
8、0.01)amongthe3groups.Conclu—sionAge,Itherapeuticdose,bloodserumTRAba
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