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时间:2017-12-07
《玻璃体内注射索拉非尼对大鼠氧诱导视网膜病变模型新生血管的作用》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、眼科新进展2014年2月第34卷第2期hap://www.yl。‘jz.comRecAdvOphthalmolVo1.34No.2February2014引文格式:田丽丽,任兵,高晓唯,罗英,蔡岩,周琨,等.玻璃体内注射索拉非尼对大鼠氧诱导视网膜病变模型新生血;管的作用[J].眼科新进展,2014,34(2):140—143.doi:lO.13389/j.cnki.rao.2014.0035【实验研究】玻璃体内注射索拉非尼对大鼠氧诱导视网膜病变模型新生血管的作用田丽丽任兵高晓唯罗英蔡岩周琨杜安杰o。#oo#oo
2、#:田丽丽,’i:i。。;Effectsofintravitrealinjectionofsorafenib出生,山东日照人,在读硕士研究生。研究方向:眼底病和眼肌学。onneovascularizationinoxygen-induced联系电话:0991-6871801;E—mail:so—phiall9@yeah.net.599104481@qq.retinopathyofratTIANLi-Li,RENBing,GAOXiao-Wei,LUOYing,CAIYan,ZHOUKun,;DUAn-dieiA
3、boutTIANLi·Li:Female,bominiDecember,1986.Masterdegree.Tel:【Keywords】sorafenib;oxygen—inducedretinopathy;;tyrosine+86-991-6871801;E—mail:sophial19kinaseinhibitorsi@yeah.net,599104481@qq.eom【Abstract】ObjectiveToinvestigatetheefectsofintravitrealinjectionofsor-
4、afenibonneovascularizationmodelofoxygen-inducedretinopathy(OIR)ofrat.Meth-收稿日期:2013-09—11odsSeven-day-oldSprague—Dawleyrats(144cases)wererandomlydividedintoCOIl-修回日期:2013—11-05j本文编辑:盛丽娜troledgroup(groupA),ROPgroup(groupB),vehicle—treatedROPgroup(groupC),;作者单
5、位:830002新疆维吾尔自5gsorafenib—treatedROPgroup(groupD),2Ogsorafenib—treatedROPgroup;治区石河子市,石河子大学医学院(groupE)and80gsorafenib—treatedROPgroup(groupA).GroupAreceivednormal:(田丽丽,周琨);830013新疆维吾partialoxygenpressure,andgroupB,C,D。EandFwereestablishedtheOmmode1.:尔自治区乌鲁木齐
6、市,解放军第474Then.atpostnatal12days.theratswerereturnedtonormaloxygentillP17.Ieratsin医院全军眼科中心(田丽丽,任兵,;高晓唯,罗英,蔡岩,周琨);044000groupsD,EandFwerereceivedintravitrealinjectionsofsorafenib(5,20and8O;山西省运城市中心医院眼科(杜安,respectively)atpostnatal12days.TheratsingroupsCwererece
7、ivedintravitrealin-i杰)jectionsofDMSO.Thentheretinaswerewholemountedandimagedwithaconfocal通讯作者:任兵,E—mail:Rb54391@microscope.Ihevascularbranchingpointswerecountedtoquantifyneovascularizationsohu.tom●inhighmagnificationatpostnatal17days.Cross—sectionsoftheretin
8、awerestainedwithReceiveddate:Sepl1.2013Accepteddate:Nov5。2013HE.ThenucleiofnewvesselsbreakingthroughtheinternalUnitingmembranewereoFromt}IeMedicalColiegeofShiheziU-countedtoquantifytheproliferat
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