《肝细胞癌中趋化因子CXCL5及其受体CXCR2的表达及意义》.pdf

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1、1936实用医学杂志2015年第31卷第12期肝细胞癌中趋化因子CXCL5及其受体CXCR2的表达及意义申九妹成元华郑启忠余梦懿摘要目的：检测趋化因子5(C—x．cmotifligand5，CXCL5)及其受体CXCR2在肝细胞癌(hepatocellularcarcinoma．HCC)中的表达，探讨其与临床病理特征的关系及其在预后评估中的意义。方法：采用免疫组化EnVision两步法检测51例HCC病例中CXCL5、CXCR2的表达，分析其与临床病理特征及微血管密度(microvesseldensity，M

2、VD)的关系。结果：(1)HCC中CXCL5、CXCR2蛋白高表达率分别为64．7％、68．6％，高于癌旁组织(17．6％、15．7％，P<0．05)；CXCL5蛋白的表达与肿瘤大小、病理分级、TNM分期及血管浸润有关；CXCR2蛋白的表达与病理分级及血管浸润有关。(2)HCC中的MVD水平高于癌旁组织(P<0．001)．与CXCL5、CXCR2的蛋白表达均呈正相关。(3)CXCL5、CXCR2蛋白高表达组，HCC复发率及转移率均较高。结论：CxcL5、CXCR2高表达可能促进了HCC的发生发展及HCC内微血

3、管生成，可用于HCC的预后评估关键词癌，肝细胞；CXCL5；CXCR2；MVD；免疫组化TheexpressionsofchemokineCXCL5anditsreceptorCXCR2inHCCandthesignificanceintheprognosticevaluationSHENJiu—mei，CHENGYuan—hua，ZHENQi—zhong，YUMeng-yi．DepartmentofPathology，XiamenHospitalofTCM，Xiarnen361009，ChinaCorres

4、pondingauthor：CHENGYuan—huaE—mail：Chengyuanhua@21cn．com【Abstract】0bjectiveTodetecttheexpressionsofchemokineCXCL5anditsreceptorCXCR2inhepatocellularcarcinoma(HCC)，investigatetheirrelationshipsbetweenCXCI-5，CXCR2andclinic0pathologicfeaturesandprobeintothesign

5、ificanceintheevaluationofprognosis．MethodsImmunohistochemicalEnvisionmethodwasutilizedtodetecttheexpressionsofCXCL5andCXCR2inHCC．toexploretheirrelationshipbetweenCXCL5，CXCR2andclinic叩athologicfeaturesandMVDinHCC．Results(1)ThehighexpressionratesofCXCL5andCXC

6、R2proteinwas64．7％and68．6％，respectively，significantlyhigherthanthoseinadjacenttissuesofHCC(17．6％，15．7％，P<0．05)．TheoverexpressionofCXCL5proteinhadcorrelationwithtumorsize，difierentiation，TNMstageandvascularinvasion(P<0．05)andtheoverexpressionofCXCR2proteindid

7、withtumorgradeandvascularinvasion(P<0．05)．(2)ThevalueofMVDwashigherinHCCthanthatintheadjacenttissuesofHCC(P<0．05)，andhadpositivecorelationwiththeexpressionsofCXCL5，andCXCR2proteins．(3)Thehigherratesofrecurenceandmetastasiswereinthegroupsofhigherexpressionof

8、CXCL5andCXCR2proteins(P<0．05)．ConclusionsTheoverexpressionsofCXCL5andCXCR2maypromotetheoccurrenceanddevelopmentofHCCaswellastheneovasculationinHCC．Therefore，theycanbeusedasmarkerstoevaluatetheprognosis