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时间:2020-04-12
《低钠血症与肝硬化腹水患者肝肾功改变及预后的关系.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、云南医药2015年第36卷第3期·283··临床研讨·低钠血症与肝硬化腹水患者肝肾功改变及预后的关系王辉,董小林,贾红萍,秦榕,尧颖,高建鹏(昆明医科大学附属延安医院消化内科,云南昆明650051)摘要:目的分析低钠血症与肝硬化腹水患者肝肾功改变及预后的关系。方法检测160例肝硬化腹水患者入院时血钠、肝肾功能等指标,分析肝硬化腹水患者低钠血症程度与肝肾功能、肝硬化相关并发症、Child—Pugh分级、MELD—Na分值及预后之间的相互关系。结果160例肝硬化腹水患者低钠血症(血清钠<135mmol/L)发生率为6
2、7.5%。血清钠120~135mmol/L、≤120mmol/L患者的病死率分别为35.1%,82.4%,90.0%死亡患者出现过不同程度低钠血症,差异有统计学意义(P3、P<0.05)。血清钠水平越低,患者肝肾功能越差,死亡率越高,血清钠水平<120mmol/L组病死率均明显高于其他组。结论肝硬化腹水患者低钠血症的发生率较高,临床可将血清钠水平作为判断肝硬化腹水患者病情严重程度及预后的指标。应引起临床重视,积极预防。关键词:肝硬化;腹水;低钠血症;肝肾功;预后中图分类号:R657.31文献标志码:A文章编号:1006—4141(2015)03—0283—04Therelationshipbetweenthechangeandprognosisofliverandrenalfunc4、tiononlivercirrhosisascitespatientswithdflufionMhyponatremia.WANGHui,DONGXiao-lin,JIAHong-ping,eta1.(Department0,Gastroenterolo-eAf~liatedYananHospitalofKunmingMedicalUniversity,YunnanKunming650051,抽Abstract:ObjectiveToanalysetherelationshipbetweenthechangean5、dprognosisofliverandrenalfunctiononlivercirrhosispatientswhocomplicatedasciteswithdilutionalhyponatremia.MethodsToexamineliverandrenalfunction,seNlmsodiumandotherindicatorsof160hospitalizedcaseswithhepatocirrhosisascites.Thentoanalysetheeorrelativitybetweenth6、elevelofdilutionalhyponatremiaandliverandrenalfunction.complicationofhepaticci卜rhosis,Child-Pughandprognosis.ResultsTheincidenceofdilutionalhyponatremiainthehepatoeirhosisascitespatientswas67.5%.Themortalityofpatientswithserumsodiumintherangeof120mmol/Land1357、mmol/Lwas35.1%.and82.4%oceumedwhenserumsodiumlessthan120mmol/L.90%ofthedeathshadencounteredthedifer—entdegreeofhyponatremia.Thedifferencewasstatisticalsignifigeontily(P<0.05).Themoreheavierthehyponatremia,themoreobviousdeteriorationofliverandkidneyfunction,th8、emorehighermorbidityofhepaticencephalopathyandhepatorenalsyndromefP
3、P<0.05)。血清钠水平越低,患者肝肾功能越差,死亡率越高,血清钠水平<120mmol/L组病死率均明显高于其他组。结论肝硬化腹水患者低钠血症的发生率较高,临床可将血清钠水平作为判断肝硬化腹水患者病情严重程度及预后的指标。应引起临床重视,积极预防。关键词:肝硬化;腹水;低钠血症;肝肾功;预后中图分类号:R657.31文献标志码:A文章编号:1006—4141(2015)03—0283—04Therelationshipbetweenthechangeandprognosisofliverandrenalfunc
4、tiononlivercirrhosisascitespatientswithdflufionMhyponatremia.WANGHui,DONGXiao-lin,JIAHong-ping,eta1.(Department0,Gastroenterolo-eAf~liatedYananHospitalofKunmingMedicalUniversity,YunnanKunming650051,抽Abstract:ObjectiveToanalysetherelationshipbetweenthechangean
5、dprognosisofliverandrenalfunctiononlivercirrhosispatientswhocomplicatedasciteswithdilutionalhyponatremia.MethodsToexamineliverandrenalfunction,seNlmsodiumandotherindicatorsof160hospitalizedcaseswithhepatocirrhosisascites.Thentoanalysetheeorrelativitybetweenth
6、elevelofdilutionalhyponatremiaandliverandrenalfunction.complicationofhepaticci卜rhosis,Child-Pughandprognosis.ResultsTheincidenceofdilutionalhyponatremiainthehepatoeirhosisascitespatientswas67.5%.Themortalityofpatientswithserumsodiumintherangeof120mmol/Land135
7、mmol/Lwas35.1%.and82.4%oceumedwhenserumsodiumlessthan120mmol/L.90%ofthedeathshadencounteredthedifer—entdegreeofhyponatremia.Thedifferencewasstatisticalsignifigeontily(P<0.05).Themoreheavierthehyponatremia,themoreobviousdeteriorationofliverandkidneyfunction,th
8、emorehighermorbidityofhepaticencephalopathyandhepatorenalsyndromefP
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