VEGF-C 和VEGF-D 在分化型甲状腺癌中的表达及意义费.pdf

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1、临床耳鼻咽喉头颈外科杂志2009年6月第23卷第12期·531·VEGF—C和VEGF—D在分化型甲状腺癌中的表达及意义，骆华杰李吉平杨腾飞王家东[摘要]目的：观察具有介导淋巴管内皮细胞和淋巴管增殖的血管内皮生长因子C，D(VEGFC，D)在分化型甲状腺癌组织芯片中的表达与意义。方法：构建布有甲状腺正常组织、腺瘤组织、有和无颈淋巴结转移甲状腺乳头状腺癌组织和甲状腺滤泡状腺癌组织共71例的组织芯片，免疫组织化学染色观察VEGF—C、VEGF—D的表达。结果：VEGF-C和VEGF-D在正常甲状腺组织中无表达，在甲状腺乳头状腺癌组

2、织的表达高于甲状腺滤泡状腺癌(P

3、nceofVEGF__CandVEGF--DindifferentiatedthyroidcarcinomaLUOHuajieLIJipingYANGTengfeiWANGJiadong(DepartmentofOto1aryngo1ogy—HeadandNeckSurgery，RenjiHospital，ShanghaiJiaotongU—niversity，Shanghai，200001，China)AbstractObjective：VEGF-C，DareknowntObecapableofinducingprolife

4、rationoflymphaticendotheliacellanddevelopmentoflymphaticvessels，SOweinvestigatedtheexpressionofVEGF-C，Dinthedifferentiatedthy—roidcarcinomatissuesmicroarrayinordertOunderstandthesignificancemechanismofcervixlymphaticmetastasisofthyroidcancer．Method：Atissuemicroarray

5、containing71specimenswasconstructed，includingnormalthyroidtissues，thyroidadenoma，papillarythyroidcarcinomawithandwithoutlymphaticmetastasis，follicularthyroidcarcinoma．VEGF—C，Dproteinexpressionwasdetectedwithimmunohistochemistry．Result：TheexpressionofVEGF—C，Dwerenoto

6、bservedinnormalthyroidtissuesandadenomatissues．TheexpressionofVEGF—C，Dinpa—pillarythyroidcarcinomawassignificantlyhigherthanthoseinfollicularthyroidcarcinoma(P％0．05)andadeno—matissues(P<0．01)．TheexpressionofVEGFC，Dinpapillarythyroidcarcinomawithlymphaticmetastasiswa

7、ssignificantlyhigherthanthoseinpapillarythyroidcarcinomawithoutlymphaticmetastasis(P％0．05)．Con。clusion：Byinducingproliferationoflymphaticendotheliacellanddevelopmentoflymphaticvessels，VEGF—C，Dcontributedtolymphaticmetastasisofpapillarythyroidcarcinoma．Keywordsthyroi

8、dneoplasms；tissuemicroarray；vascularendothelialgrowthfactor—C；vascularendothelialgrowthfactorD血管内皮生长因子C和D(vascularendothe—性肿瘤之一，分化型甲状腺癌中甲状