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1、中华现代内科学杂志JournalofChineseModernMedicine2006年第3卷第9期·969··论著·不同分期支气管哮喘肺功能、嗜酸粒细胞的不同表达杨美艳,郭冰[摘要]目的观察哮喘患者急性发作期、缓解期的肺功能和血嗜酸粒细胞(EOS)的变化,探讨其临床意义。方法对57例急性发作期哮喘患者做肺功能测定和取外周血进行EOS的计数,经治疗后选取符合缓解期标准的患者50例,也做肺功能测定和外周血EOS的计数,比较两期患者肺功能及EOS测定结果。FEV/FVC比值≥70%为肺功能正常,50%1及25%用力肺活量时呼气流速(V50、V25)实测值/预测值<70%
2、为小气道功能异常。结果急性发作期哮喘患者外周血EOS明显高于缓解期组(P<0.01),急性发作期患者肺功能FEV1明显低于缓解期,差异有显著性(P<0.05)。V50、V25在急性发作期与缓解期相比较均差异无显著性(P>0.05)。EOS与FEV、V、V呈显著负相关(P<0.05)。结论外周血15025EOS在哮喘急性发作时明显增加,提示EOS是反映气道炎症程度的可靠指标。反映小气道功能的V50、V25在急性发作期与缓解期变化不大,多数患者在缓解期仍存在小气道功能异常,提示缓解期气道炎症仍持续存在,需要做长期的维持治疗。[关键词]哮喘;嗜酸粒细胞;肺功能;气道炎症;
3、急性发作期;缓解期+[中图分类号]R562.25[文献标识码]A[文章编号]1681-6676(2006)09-0969-02LungfunctionandeosinophilvariedreflectondifferentperiodofbronchiaasthmaYANGMei-yan,GUOBing.DepartmentofRespiratory,TraditionalChineseMedicineHospitalofMaoming,Maom-ing525000,China[Abstract]ObjectiveWeexploretheclinicusageac
4、cordingtoobservingthechangeoflung-functionsandeosinophil(EOS)betweentheacute-outbreakperiodandcatabaticperiodofasthmasufferers.MethodsChoo-sing57acute-outbreakasthmasufferers,thencheckingoutthelung-functionsandtakingtheEOScountofperiph-eralblood.Choosing50patientsthatmetthestandardofca
5、tabaticperiodaftertreatment.Wealsosurveythelung-functionandtheEOScountofperipheralbloodofthe50patients.Comparingwiththedataoftwogroups.IfFEV1/FVC≥70%,normal;ifthevelocityofflowof50%and25%vitalcapacity(V50、V25)fact/predict<70%,symbolizingsmalltracheafunctionsabnormal.ResultsTheperiphera
6、lblood곰sEOSofacute-outbreakpe-riodgroupisobviouslyhigherthanthecatabaticperiodgroup곰s(P<0.01).Thelung-functionofacute-outbreakgroupisobviouslylowerthanthecatabaticgroup곰s(P<0.05).ThereislittledifferencebetweenV50andV25nomatterinacute-outbreakperiodorcatabaticperiod(P>0.05).EOSandFEV1、V
7、50andV25areminusrelated.ConclusionTheperipheralblood곰sEOSincreaseswhenasthmabreakouts.TheEOSisareliablesignalthatre-flectsthegradesoftracheainflammation.V50andV25whichrepresentthefunctionsofsmalltracheadon곰tchangemuchinboththetwoperiods.Majorityofthepatientsstillhaveabnormalsmalltrac
