不同分期支气管哮喘肺功能、嗜酸粒细胞的不同表达

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1、不同分期支气管哮喘肺功能、嗜酸粒细胞的不同表达［摘要］目的观察哮喘患者急性发作期、缓解期的肺功能和血嗜酸粒细胞(EOS)的变化，探讨其临床意义。方法对57例急性发作期哮喘患者做肺功能测定和取外周血进行EOS的计数，经治疗后选取符合缓解期标准的患者50例，也做肺功能测定和外周血EOS的计数，比较两期患者肺功能及EOS测定结果。FEV1/FVC比值≥70%为肺功能正常，50%及25%用力肺活量时呼气流速(V50、V25)实测值/预测值＜70%为小气道功能异常。结果急性发作期哮喘患者外周血EOS明显高于缓解期组(P＜0.0

2、1)，急性发作期患者肺功能FEV1明显低于缓解期，差异有显著性(P＜0.05)。V50、V25在急性发作期与缓解期相比较均差异无显著性(P＞0.05)。EOS与FEV1、V50、V25呈显著负相关(P＜0.05)。结论外周血EOS在哮喘急性发作时明显增加，提示EOS是反映气道炎症程度的可靠指标。反映小气道功能的V50、V25在急性发作期与缓解期变化不大，多数患者在缓解期仍存在小气道功能异常，提示缓解期气道炎症仍持续存在，需要做长期的维持治疗。［关键词］哮喘；嗜酸粒细胞；肺功能；气道炎症；急性发作期；缓解期Lungfu

3、nctionandeosinophilvariedreflectondifferentperiodofbronchiaasthma8［Abstract］ObjectiveWeexploretheclinicusageaccordingtoobservingthechangeoflung-functionsandeosinophil(EOS)betweentheacute-outbreakperiodandcatabaticperiodofasthmasufferers.MethodsChoosing57acute-o

4、utbreakasthmasufferers，thencheckingoutthelung-functionsandtakingtheEOScountofperipheralblood.Choosing50patientsthatmetthestandardofcatabaticperiodaftertreatment.Wealsosurveythelung-functionandtheEOScountofperipheralbloodofthe50patients.Comparingwiththedataoftwo

5、groups.IfFEV1/FVC≥70%，normal;ifthevelocityofflowof50%and25%vitalcapacity(V50、V25)fact/predict＜70%，symbolizingsmalltracheafunctionsabnormal.ResultsTheperipheralblood’sEOSofacute-outbreakperiodgroupisobviouslyhigherthanthecatabaticperiodgroup’s(P＜0.01).Thelung-fu

6、nctionofacute-outbreakgroupisobviouslylowerthanthecatabaticgroup’s(P＜0.05).ThereislittledifferencebetweenV50andV25nomatterinacute-outbreakperiodorcatabaticperiod(P＞0.05).EOSandFEV1、V50andV25areminusrelated.ConclusionTheperipheralblood’sEOSincreaseswhenasthmabre

7、akouts.TheEOSisareliablesignalthatreflectsthegradesoftracheainflammation.V50andV258whichrepresentthefunctionsofsmalltracheadon’tchangemuchinboththetwoperiods.Majorityofthepatientsstillhaveabnormalsmalltracheasymptomswhichisasignalreflectingthetracheainflammatio

8、nandneedacontinuouslytreatment.［Keywords］asthma;eosinophil;lung-function;tracheainflammation;acute-outbreakperiod;catabaticperiod支气管哮喘是多种细胞和细胞组份参与的慢性气道炎症性疾患［1］。研究发现，粒—巨噬细胞集落