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1、-3208-中国误诊学杂志2005年12月第5卷第17期ChineseJournalofMisdiagnostics,December2005,Vol5No.17【研究原著】罗格列酮影响2型糖尿病患者颈动脉内膜中层厚度及斑块的超声评价张鸿飞1212,肖立中,林晓云,江志平【摘要】目的:应用颈动脉超声评价2型糖尿病患者罗格列酮长期治疗后颈动脉内膜中层厚度及斑块变化。方法:选择59例2型糖尿病并肥胖患者,随机分成对照组(n=29)与治疗组(n=30),后者加用罗格列酮治疗24个月,治疗前后应用高频超声检测颈动脉内膜中层厚度(IMT)及斑块,同
2、时测定血清一氧化氮(NO)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)。结果:与对照组比较,治疗组IMT及斑块检出率降低(P<0.01及0.05),血清NO增加,CRP、TNF-α降低(P<0.01);与治疗前比较,对照组IMT增加(P<0.01),斑块检出率及血清NO,CRP、TNF-α无明显变化(P>0.05)。结论:罗格列酮长期治疗能延缓2型糖尿病患者颈动脉粥样硬化进展,稳定斑块。【主题词】糖尿病,Ⅱ型/药物疗法;颈动脉疾病/超声检查;颈动脉/超声检查;血管内膜/超声检查;噻唑烷二酮类/治疗应用【中图分类号】R587.2
3、【文献标识码】A【文章编号】1009-6647(2005)17-3208-03UltrasonicEstimationofEffectsofRosiglitazoneonCarotidIntima-MediaThicknessandPlaqueinPatientswithType2DiabetesMellitusZHANGHong-fei,XIAOLi-zhong,LINXiao-yun,etal.(HospitalofShaoguanUniversity,Shaoguan512005)【Abstract】Objective:Toinve
4、stigatethetherapeuticeffectsofrosiglitazoneoncarotidintima-mediathickness(IMT)andarterialplaqueinpatientswithtype2diabetesmellitus(DM)bycarotidultrasonography.Methods:59casesofobeseDMwererandomlydividedintotwogroups:Controlgroup(n=29)receivedroutinetherapyalone,Treatgroup
5、(n=30)receivedtherapywithrosiglitazoneonthebasisofroutinetherapyfor24months.CarotidIMTandarterialplaqueweremeasuredbycarotidultrasonographybeforeandafterthetreatment,serumnitricoxide(NO),C-reactiveprotein(CRP),tumornecrosisfactor-α(TNF-α)levelwereassayedalso.Results:Compa
6、redwithcontrolgroup,theIMTandcarotidarterialplaqueweredecreasedafterrosiglitazonetreatment(P<0.01and0.05),serumNOincreased,CRP,TNF-αdecreasedalso(P<0.01).Comparedwithpretherapy,IMTincontrolgroupwasincreased(P<0.01),Nosignificantchangewasfoundinpercentageofdetectionofcarot
7、idarterialplaqueandserumlevelofNO,CRP,TNF-α(P>0.05).Conclusion:Rosiglitazonecanretardatherosclerosisprogressionandstablearterialplaqueinobesepatientswithtype2DM.【MeSH】Diabetesmellitus,typeⅡ/drugtherapy;Carotidarterydiseases/ultrasonography;Carotidarteries/ultrasonography;
8、TunicaIntima/ultrasonography;Thiazolidinediones/therapeuticuse2型糖尿病(DM)因容易形成动脉粥样硬化(AS)动脉粥样硬化进展的影
