改良FOLFOX6新辅助化疗与术后化疗治疗进展期胃癌的应用效果比较.doc

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1、改良F0LF0X6新辅助化疗与术后化疗治疗进展期胃癌的应用效果比较［摘要］目的比较进展期胃癌应用改良F0LF0X6新辅助化疗与术后化疗治疗的效果。方法抽取2009年11月〜2012年12月我院的进展期胃癌患者46例作为本次实验的研究对象，将其随机分为对照组和实验组。对照组23例进展期胃癌患者采取改良F0LF0X6术后辅助化疗进行治疗，实验组23例进展期胃癌患者采取改良F0LF0X6新辅助化疗进行治疗，两组进展期胃癌患者均随访3年，比较两组进展期胃癌患者的近期疗效、3年生存率、肿瘤进展时间及不良反应发生率。结果对照组进展期胃癌患者的不良反应发生率（47.83%）显著高于实验组（21.74

2、%）；实验组和对照组进展期胃癌患者的近期疗效、3年生存率、肿瘤进展时间比较，差异有统计学意义（P〈0.05）。结论对进展期胃癌患者应用改良F0LF0X6新辅助化疗，能冇效提高患者的生存吋间及生存质量，且毒副作用较小。［关键词］进展期胃癌；改良F0LF0X6；新辅助化疗；术后化疗；效果［中图分类号1R735.2［文献标识码］A［文章编号11674-4721（2016）06（b）-0047-03ApplicationeffectcomparisonofimprovedF0LF0X6neoadjuvantchemotherapyandpostoperativechemotherapyintr

3、eatingprogressivestomachcancerMENGQing-boDepartmentofGeneralSurgery,theThirdpeople'sHospitalofTonghuainJilinProvince,Tonghua134000,China[Abstract]ObjectiveToanalyzetheeffectofimprovedF0LF0X6neoadjuvantchemotherapyandpostoperativechemotherapyinprogressivestomachcancer・Methods46progressivestomachc

4、ancerpatientsfromNovember2009toDecember2012ofourhospitalwereselectedasstudyobjectforthisstudy.46progressivestomachcancerpatientswererandomdividedintocontrolgroupandexperimentalgroup.23progressivestomachcancerpatientsincontrolgroupwereusedimproveF0LF0X6postoperativechemotherapyand23progressivesto

5、machcancerpatientsinexperimentalgroupwereusedimproveF0LF0X6neoadjuvantchemotherapy.Thefol1owedupofprogressivestomachcancerpatientsintwogroupswere3years.Theshorttermeffect,three-yearsurvivalrate,timetotumorprogressionandtheincidencerateofadverseeffectsofprogressivestomachcancerpatientsintwogroups

6、wereanalyzedandcompared.ResultsTheincidencerateofadverseeffectsofprogressivestomachcancerpatientsincontrolgroupwas47.83%,obvioushigherthanthatwas21.74%inexperimentalgroup,andtheshorttermeffect,three-yearsurvivalrate,timetotumorprogressionofprogressivestomachcancerpatientsbetweentwogroupshadstati

7、sticalsignificanee(P<0.05).ConclusionUsingimprovedF0LF0X6neoadjuvantchemotherapyforprogressivestomachcancerpatientscanenhancethesurvivaltimeandqualityofpatientseffectively,andwithlittleadverseeffects・［Keywords］Progressivesto