局部进展期胃癌根治术后同期放化疗与单纯化疗的临床比较

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1、•252•中华放射神输学杂&R12年5月第21栓第3期EhinJRadimgoLM・y2012,。1・21,No・3•腹部肿瘤・局部进展期胃癌根治术后同期放化疗与单纯化疗的临床比较杨治花折虹闻钢詹文华张自新丁誌【摘要】目的比较耐部进展期肖桶根治术后同期放化疗(MT)与单纯化疗(CT)的疔效和不良反应。方法83例总者随机分为RCT组(43例)和CT组(40例)。RCT组采用三维适形放疗45Cy同期LI服卡培他滨化疗(1600mg/m2)，放疗结束2周后继续用F0LF0X4方案巩固化疗4-6周期cCT组采用FOLFOX4方案化疗6-8周期,Kaplan-Meier法计算生存率等并仏如检验结果随

2、访率为96%,RCT和CT纽随访时间満2、3年者分别为37、12例和31、10例cRCT组和CT组1、2、3年局部控制率分别为100%57%.94%和95%.87%,73%(X2=4.54,P=0.033),生存平分别为98%,86%.81%和93%.80%.64%(x2=3.96,P=0.047)oRCT绍和CT组治疗期何玄3级白细胞*降发生率分别为23%和15%(x2=0.93,P=0.630),>3级胃肠道反应发牛.举分别为16%和)0%(X：=0.95,P=0.624)。结论局部进展期胃癌根治术后RCT比CT可提高患祥局部捽制半和牛存率•不良反应可耐受。【关飲词】胃肿福/放射疗法；

3、烂肿瘤/化学疗法；综合疗医；侦后ClinicalrandomzicdstudyofpostoperativeradiochemotherapycompareduithchemotherapyaloneinthetreatmentoflocallyadvancedgustrkcancerYANGZhihua.ZHEHong9YANGang.ZHANWeu-huavZHANGZi・xin.DINGZhe.DepartmentofRadiationOntology.GeneralHospitalofNingx^aMedicalUniversilyfYinchuan750004.ChinaCorr

4、espondingauthortZHEHongtEmail:123zhehong@una.com[Abstract]ObjectiveToinvestigatetheefficacyandtoxicityofpoMoperativeradiochemotherapycomparedwithchemolherapyaloneintheIrratmrnloflocallyadvanced眇trieameer・MethodsAtotalof83patientswithresectedadenocarcincmaoftheMomachwerenuiducdyalignedtopostoperati

5、veradioch^motherapygroup(KCT)(n«43)orchemolherapyalorw*group((JT)(n=40).PatientsinRCTgroupreceivedradiotherapyconcuiTenlwithcapecitabinechcmothrrapythenfollowedby4-6cyclesofFOLFOX4chemudienipy.Thetotaldoseofradiationwas45Cy.Thed

6、tF0LbX)X4chemotherapy・SurvivalwasanalyzedumngKaplan-MeiermrlhodandLogranktebl.ResultsThefollow-upratewan96%.numberofpatientswhohadaminimumof2・.3・yearfollow-uptime“ere37.12intheRCTgroupand31JOintheCTgroup.Tlw*l・.2・.3・yenrlocalcontrolratesforKCTanilCTgr(x>

7、Mwere100%>97%.94%and95%.87%c73%()(2=4.54.P=

8、0・033)■respectively.Hie1・.2・.3・yearsurvivalrat»were98%.36%t8i%intheRCTgroup9with93%,80%.64%intheCTgroup(x‘=3.96,P=0.047).Theincidenceofgrade3hematologicaltoxicityintheRCTandCTgroupwas23%vs15%(x'=0・93.P=0.630).and