N-芳基吡咯烷的微波水相简便合成.pdf

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1、第202311卷年第77月期化学研究与应用V01．23．No．7ChemicalResearchandApplicationJuly，201l文章编号：1004-1656(2011)07-0955-06ConvenientaqueoussynthesisofN-arylpyrrolidinesundermicrowaveirradiation，LIHong-bo’，LIANGWu，WANGLong—fei，LIULang，CHENKai，WUYi(SchoolofMaterialsScienceandEngineering，SouthwestUniversityofScie

2、nceandTechnology，Mianyang621010，China)Abs：AseriesofN-arylpyrrolidinesfromarylaminesand1，4-dimesyloxybutaneweredeveloped(yieldwas,11．4％一83．6％)U．singmicrowaveirradiationinanaqueouspotassiumcarbonatemedium．Thereactionwasperformedatatmosphericpressureandtheproductswerepurifiedwithextractionope

3、ration．Thismethodhadsomeadvantagesofoperationalsafety，mildconditionsandconven．iencetofinaltrcatmenLKeywords：N-arylpyrrolidine；arylamine；1，4-dimesyloxybutane；microwave中图分类号：0626．13文献标识码：AⅣ一芳基吡咯烷的微波水相简便合成李鸿波，梁伍，王龙飞，刘浪，陈凯，吴毅(西南科技大学材料科学与工程学院，四川绵阳621010)摘要：微波辐射下，以芳胺和1，4-丁二醇二甲磺酸酯为起始原料。在碳酸钾水溶液中发生

4、环缩合反应，一步生成Ⅳ_芳基吡咯烷(产率11．4％-83．6％)。该反应在常压条件下进行，产品用萃取方法纯化，该工艺具有操作安全，反应条件温和，后处理简便等优点。关键词：Ⅳ_芳基吡咯烷；芳胺；l，4-丁二醇二甲磺酸酯；微波Pyrrolidinesarecommonstructuralsubuni~pres-actionconditions[13_¨】．orviacouplingreactionsusingentinnaturalandunnaturalproducts．Dependinguponexpensivemetal[-oractivemesoporousA103as

5、2thesubstituents，pyrrolidineshavebeenreportedtocatalyst[18]．AllthemethodswereefficientandSUC-possessavarietyofimportantbiologicalactivities[1．7]，cessfulbuttheyallneededcatalysts，longreactionincludingantibacterial，neuromodulatory，glycosida-timesorhi【ghreactiontemperature．Recentlyaone-seinhi

6、bitory，andfungicidalactivities．Amongthese，N-potsynthesisofN-arylpyrrolidinesfromarylaminesarylpyrrolidines，animportantclassofcompounds，wereand1，4一dihalobutane(1，4一ditosyloxybutane)wasex-preparedviaalkylationofarylamineswitIlglycoldisul—ploredviamicrowave-assistedorganicsynthesisfonateinorg

7、anicsolventforlongtimes[8-lo]，using(MAOS)inamildlybasicaqueousmediumt蚴】．Butcomplicatedmultistepreactions⋯，underharshre．inthisprocedure，thereactionoccurredunderhish收稿日期：2011-03-01：修回日期：2011-05-22基金项目：四川省科技厅资助项目(2006J13-143)；西南科技大学引进人才资助项目(053115)联系人简介：李鸿波(1973·