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时间:2020-03-21
《重组人脑利钠肽与硝普钠治疗难治性心力衰竭的临床效果观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、·2840·职业与健康2014年10月第3O卷第19期OccupandHealth,Oct.2014,Vo1.30,No.19·基础与临床医学·重组人脑利钠肽与硝普钠治疗难治性心力衰竭的临床效果观察Clinicalobservationofrecombinanthumanbrainnatriureticpeptideandsodiumnitroprussideinthetreatmentofrefractoryheartfailure姜琪华,王引线,李全利,丁海峰JIANGQi—hua,WANGYin—xian,LIQuan—li,DINGHai-feng陕西省宝鸡市第二人民医院,
2、721000摘要:目的观察重组人脑利钠肽与硝普钠治疗难治性心力衰竭的临床疗效。方法将102例住院治疗的难治性心力衰竭患者随机分为观察组、对照组,各5l例,并分别给予重组人脑利钠肽与硝普钠,连续治疗7天后观察其疗效。结果观察组总有效率(90.20%)明显优于对照组(74.51%),2组差异有统计学意义(P<0.05)。两组患者左室射血分数、每搏输出量、心输出量、心脏指数、血尿素氮、超级c反应蛋白(hs—CRP)均有改善,观察组均优于对照组(P<0.05)。结论重组人脑利钠肽可改善难治性心力衰竭患者的心功能,提高患者生存质量,其疗效优于硝普钠,其使用安全性与硝普钠相当。关键词:难治性心
3、力衰竭;重组人脑利钠肽;硝普钠中国图书资料分类号:R453文献标识码:A文章编号:1004—1257(2014)19—2840—03ClinicalobservationofrecombinanthumanbrainnatriureticpeptideandsodiumnitroprussideinthetreatmentofrefractoryheartfailureJIANGQi-hua.WANGYin—xian.LIQuan—li.DINGHai-fengBaojiSecondPeople’SHospital,Shanxi,721000,ChinaAbstract:[Obje
4、cfive]Toobservetheclinicaleficacyofrecombinanthumanbrainnatriureticpeptideandsodiumnitroprussideinthetreatmentofrefractoryheartfailure.[Methods]Atotalof102inpatientswithrefractoryheartfailurewererandomlydividedintoobservationgroupandcontrolgroup,51casesineachgroup,andweretreatedwithrecombinant
5、humanbrainnatriureticpeptideandsodiumnitroprussiderespectively.Theefectwasobservedaftercontinuous7-day.treatment.[Results]Totaleffectiverateofobservationgroup(90.20%)isobviouslybetterthanthecontrolgroup(74.51%),withsignificantdifference(P<0.05).Theleftventricularejectionfraction,strokevolume,c
6、ardiacoutput,cardiacindex,bloodureanitrogen,hs—CRPofpatientsinboth2groupswereimproved,theobservationgroupwasbetterthanthecontrolgroup(P<0.05).[Conclusion]Recombinanthumanbrainnatriureticpeptidecanimprovecardiacfunctioninpatientswithrefractoryheartfailure,improvethequalityoflifeofpatients,itscu
7、rativeeffectisbetterthanthatofsodiumnitroprusside,anditsclinicalsecurityisthesameassodiumnitroprusside.Keywords:Refractoryheartfailure;Recombinanthumanbrainnatriureticpeptide;Sodiumnitroprusside随着人口老龄化和人群饮食结构的改变,心血管8.92)岁;冠心病34例,高血压心脏病1
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