可乐定控释贴治疗儿童抽动障碍的临床研究【临床医学毕业论文设计，精品】.doc

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1、临床医学论文•可乐定控释贴治疗儿童抽动障碍的临床硏究作者：张红宇，林悦，刘美娜，邹小兵【关键词】可乐定控释贴;抽动障碍;儿童摘要〕目的：探讨可乐定控释贴治疗儿童抽动障碍的临床疗效。方法：92例TICS患儿随机分为硏究组25例(予可乐定控释贴治疗)、氟哌(I定醇组38例(予氟哌U定醇治疗)和泰必利组29例(予泰必利治疗)，采用耶鲁抽动症整体严重度量表(YGTSS)评分并记录治疗中可能山现的不良反应，共治疗12周。结果：治疗笫12周末硏究组有效率为84.0%氟哌碇醇组为68.4%泰必利组为65.5%(P均＞0.05);不良反应较轻且发生率(16.0%)明显低于氟哌碇醇组(65・8%)(

2、P＜0.01)和泰必利组(48.3%)(P＜0.05);平均显效时间硏究组(45.65±8.57)d与氟哌碇醇组(40.81±6.79)d和泰必利组(42.34±7・92)d相当(P均＞0.05);硏究组YGTSS总分减分率(64.90+10.49)%高于氟哌口定醇组(42.73+11.90)%和泰必利组(40.63±13・58)%(P均＜0.05)。结论：可乐定控释贴治疗抽动障碍疗效优于氟哌碇醇和泰必利，不良反应较轻且发生率低。关键词〕可乐定控释贴;抽动障碍;儿童Clonidineskinpasterversushaloperidolandtiaprideinthetreatme

3、ntofchildrenwithTourette'ssyndrome[Abstract〕Objectivc:Toevaluatetheefficacyandtolcrabi1ityofclonidineskinpasterincomparisonwithhaloperidolandtiaprideinthetreatmentofchildrcnwithTourcttc*ssyndromc(TS)・Methods:Total92TSpatientsweredividedintostudygroupof25cases(treatedwithclonidineskinpaster)jha

4、loperidolgroupof38cases(treatedwithhaloperidol)andtiapridcgroupof29cascs(treatedwithtiapridc)‘andthepcriodoftreatmentwasl2weeks.AllthecaseswerescoredbytheYaleGlobalTicSeverityScale(YGTSS)，andtherewerenosignificantdifferenceinYGTSSscoresbetweenthreegroupsatthebeginningofthestudy.Results:Theprop

5、ortionofefficaciouscasesinclonidineskinpastergroup(84.0%)appearedslightlyhigherthanthatinhaloperidolgroup(68.4%，P>0・05)andtiapridegroup(65.5%?P>0.05);theproportionofsideeffectsinstudygroup(16.0%)wassignificant1owerthanthatinhaloperidolgroup(65.8%，PvO.01)andtiapridegroup(48.3%JP<0.05);therewasn

6、odifferenceinmeanremissiontimebetweenthreegroups(45・65±8.57)dj(40.81±6.79)dand(42・34±7・92)drespectivcly(P>0.05)・ClonidineskinpasterproducedahigherreductionintheYGTSS(64.90±10.49)%thanhaloperidol(42.73±11.90)%(P<0.05)andtla-pride(40.63+13.58)%(P<0.05).Conclusions:Inthispilotstudy5clonidineskinp

7、asterwasdemonstratedabetterefficacythanhaloperidolandtiaprideinthetreatmentofchildrenwithTS5anditssideeffectswasmiIdandrare・〔Keywords^Clonidineskinpaster;Ticdisorder;Children抽动障碍（TicdisordciJ起病于儿童和青少年时期，主要表现为不自主的、反复的、快速的一个或多部位肌肉运动性抽动和发声