可乐定控释贴治疗儿童抽动障碍临床探究

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1、可乐定控释贴治疗儿童抽动障碍临床探究作者：张红宇，林悦，刘美娜，邹小兵【关键词】可乐定控释贴;抽动障碍；儿童摘要］目的：探讨可乐定控释贴治疗儿童抽动障碍的临床疗效。方法：92例TICS患儿随机分为研究组25例(予可乐定控释贴治疗)、氟哌唳醇组38例(予氟哌唳醇治疗)和泰必利组29例(予泰必利治疗)，采用耶鲁抽动症整体严重度量表(YGTSS)评分并记录治疗中可能出现的不良反应,共治疗12周。结果：治疗第12周末研究组有效率为84.0%,氟哌唳醇组为68.4%,泰必利组为65.5%(P均>；0.05)；不良反应较轻且发生率(16.0%)明显低于氟哌唳醇组(6

2、5.8%)(P<；0.01)和泰必利组(48.3%)(P<；0.05)；平均显效时间研究组(45.65±8.57)d与氟哌除醇组(40.81±6.79)d和泰必利组(42.34±7.92)d相当(P均>；0.05)；研究组YGTSS总分减分率(64.90±10.49)%髙于氟哌唳醇组(42.73±11.90)%和泰必利组(40.63±13.58)%(P均<；0.05)。结论：可乐定控释贴治疗抽动障碍疗效优于氟哌唳醇和泰必利，不良反应较轻且发生率低。关键词］可乐定控释贴；抽动障碍；儿童Clonidineskinpasterversushalop

3、eridolandtiaprideinthetreatmentofchildrenwithTourette，ssyndrome[Abstract]Objective：ToevaluatetheefficacyandtolerabilityofcionidineskinpasterincomparisonwithhaloperidolandtiaprideinthetreatmentofchildrenwithTourette，ssyndrome(TS)・Methods：Total92TSpatientsweredividedintostudygroupof2

4、5cases(treatedwithclonidineskinpaster),haloperidolgroupof38cases(treatedwithhaloperidol)andtiapridegroupof29cases(treatedwithtiapride),andtheperiodoftreatmentwasl2weeks.AllthecaseswerescoredbytheYaleGlobalTicSeverityScale(YGTSS),andtherewerenosignifiesntdifferenceinYGTSSscoresbetwe

5、enthreegroupsatthebeginningofthestudy.Results：Theproportionofefficaciouscasesinclonidineskinpastergroup(84.0%)appearedslightlyhigherthanthatinhaloperidolgroup(68・4%,P>；0.05)andtiapridegroup(65.5%,P>；0.05)；theproportionofsideeffectsinstudygroup(16・0%)wassignificantlowerthanthati

6、nhaloperidolgroup(65.8%,P<；0.01)andtiapridegroup(48.3%,P<；0.05)；therewasnodifferenceinmeanremissiontimebetweenthreegroups(45.65±8.57)d,(40.81±6.79)dand(42.34±7.92)drespectively(P>；0.05).ClonidineskinpasterproducedahigherreductionintheYGTSS(64.90+10.49)%thanhaloperidol(42.73±1

7、1.90)%(P<；0.05)andtia-pride(40.63±13.58)%(P<；0.05)・Conclusions：Inthispilotstudy,clonidineskinpasterwasdemonstratedabetterefficacythanhaloperidolandtiaprideinthetreatmentofchildrenwithTS,anditssideeffectswasmildandrare・[Keywords]Clonidineskinpaster；Ticdisorder；Children抽动障碍(Ticdi

8、sorder)起病于儿童和青少年时期，主要表现为不自