临床医学论文-可乐定控释贴治疗儿童抽动障碍的临床研究

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1、临床医学论文•可乐定控释贴治疗儿童抽动障碍的临床研究作者：张红宇，林悦，刘美娜，邹小兵【关键词】可乐定控释贴;抽动障碍;儿童摘要]目的：探讨可乐定控释贴治疗儿童抽动障碍的临床疗效。方法：92例TICS患儿随机分为研究组25例(予可乐定控释贴治疗)、氟哌喘醇组38例(予氟哌I定醇治疗)和泰必利组29例(予泰必利治疗)，采用耶鲁抽动症整体严重度量表(YGTSS)评分并记录治疗屮可能出现的不良反应，共治疗12周。结果：治疗第12周末研究组有效率为84.0%,氟哌喘醇组为68.4%,泰必利组为65.5%(P均＞

2、0.05);不良反应较轻且发生率(16.0%)明显低于氟哌呢醇组(65.8%)(P＜0.01)和泰必利组(48.3%)(P＜0.05);平均显效时间研究组(45.65±8.57)d与氟哌I定醇组(40.81±6.79)d和泰必利组(42.34±7.92)d相当(P均＞0.05);研究组YGTSS总分减分率(64.90±10.49)%高于氟哌睫醇组(42.73±11.90)%和泰必利组(40.63±13.58)%(P均＜0.05)«结论：可乐定控释贴治疗抽动障碍疗效优于氟哌噪醇和泰必利，不良反应较轻月•发

3、生率低。关键词]可乐定控释贴;抽动障碍;儿童ClonidineskinpasterversushaloperidolandtiaprideinthetreatmentofchildrenwithTourette'ssyndrome[Abslracl]Objective:Toevaluatetheefficacyandtolerabi1ityofclonidineskinpasterincomparisonwithhaloperidolandtiaprideinthetreatmentofchildren

4、withTourette'ssyndromeCTS)・Methods:Total92TSpatientsweredividedintostudygroupof25cases(treatedwithclonidineskinpaster),haloperidolgroupof38cases(treatedwithhaloperidol)andtiapridegroupof29cases(treatedwithtiapride),andtheperiodoftreatmentwasl2weeks.Allth

5、ecaseswerescoredbytheYaleGlobalTicSeverityScale(YGTSS),andtherewerenosignificantdifferenceinYGTSSscoresbetweenthreegroupsatthebeginningofthestudy.Results:Theproportionofefficaciouscasesinclonidineskinpastergroup(84.0%)appearedslightlyhigherthanthatinhalo

6、peridolgroup(68.4%,P>0・05)andtiapridegroup(65.5%,P>0.05);theproportionofsideeffectsinstudygroup(16.0%)wassignificant1owerthanthatinhaloperidolgroup(65.8%,PvO.Ol)andtiapridegroup(48.3%,Pv0・05);therewasnodifferenceinmeanremissiontimebetweenthreegroups(45・6

7、5±8.57)d,(40.81±6.79)dand(42.34土7・92)drespectively(P>0.05).ClonidineskinpasterproducedahigherreductionintheYGTSS(64.90±10.49)%thanhaloperidol(42.73±11.90)%(P<0.05)andtia-pride(40.63±13.58)%(P<0.05).Conclusions:Inthispilotstudy,clonidineskinpasterwasdemon

8、stratedabetterefficacythanhaloperidolandtiaprideinthetreatmentofchildrenwithTS,anditssideeffectswasmildandrare・[KeywordslClonidineskinpaster;Ticdisorder;Children抽动障碍（Ticdisorder）起病于儿童和青少年时期，主要表现为不口主的、反复的、快速的一个或多部位肌肉运动性抽动和发