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1、TIMI1561No.ofPages4ForumBat-Originchancetopromotecross-speciesviralSARS-CoV,andalphacoronaviruses,transmission.Forinstance,pigsaresus-respectively,wereused.PhylogenywasCoronavirusesExpandceptibletoinfectionwithhumanandavianreconstructedusingconservedregionsTheirHostRangetoinfluenzaAviruses(IAVs
2、),suchasH1N1ingenomesbythemaximumlikelihoodandH3N2,whichthenreassorttoinfectmethodwith300replicates(Figure1A).Pigshumans[4].Thus,pigsareregardedasConsistentwithpreviousstudies,phyloge-12mixingvesselsforIAVs.However,pigsneticanalysisshowsthatSeACoVswereLiangWang,ShuoSu,1,33werenotknowntobesusce
3、ptibletocloselyrelatedtotheRhinolophusbatYuhaiBi,GaryWong,andbat-origincoronavirusesuntilrecently,coronavirusHKU2isolatedinsouthern1,3,4,*GeorgeF.GaowhentwoindependentgroupsreportedChina(Figure1A).SeACoVwasfoundtothedetectionofnovelswineentericshareacommonancestorwithhumanInfectionswithbat-ori
4、gincorona-alphacoronaviruses(SeACoVs)distinctcoronavirus229E/NL63,butthesevirusesviruseshavecausedsevereillnessfromknownswinecoronaviruses(witharedistantfromotherknownswinealpha-inhumansby‘hostjump’.onegroupsuccessfullyisolatinglivecoronaviruses,indicatingtheirdifferentori-Recently,novelbat-or
5、igincorona-virus).TheSeACoVswerefoundtobegins.FurtheranalysisontheSgene,whichviruseswerefoundinpigs.Thephylogeneticallyclosetobatcoronavirusdeterminesvirusattachment,hostcelllargenumberofmutationsontheHKU2[5,6].Thissuggeststhatbat-originentry,and‘hostjump’ofcoronavirusesreceptor-bindingdomaina
6、llowedcoronavirusesmayhave‘jumped’the[7],showedthatdomain0intheS1subunitthevirusestoinfectthenewhost,speciesbarriertoinfectpigs.hasstructuralsimilaritytothatofNL63.TherestofthedomainontheS1subunitposingapotentialthreattobothwassimilartothatofmurinehepatitiscoro-agricultureandpublichealth.TheEm
7、ergenceofBat-Originnavirus(betaCov)[6].Therewere11res-CoronavirusesInfectingPigsiduesofthereceptor-bindingdomainCoronavirusTransmissioninInFebruary2017,outbreaksofsevere(RBD,alsocalledC-terminaldomain,Wildlifewaterydiarrheaofsucklingpig
