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1、T1BS-Janua~198517ReviewsThenovelglycoproteinsofpa~i~cacidiscovalentlyboundtoE2,andthisacylationprobablyoccursastheglycoproteinistransportedthroughthecoronavlrusesGolgiapparatus.VirionsformbybuddingfromRERLawrenceSturmanandKathrynHolmesandGolgimembranesandarereleasedfromthecellapparentlyviathecellul
2、arsecretoryapparatus.Becauseviralcom-Thetwoglycoproteinsofcoronavirusenvelopeshavedifferentfunctionsinintracellu-ponentsassembleatRERandGolgilarbudding,cytopathiceffectsandvirusinfectivity,andhavemarkedlydifferentmembranes,subsequentprocessingofbiochemicalproperties.E2mayoccurasintactvirionsaretran
3、s-portedthroughintracellularcompart-Glycoproteinsofviralenvelopesmedi-Uponentryintothecell,thepositive-ments.Pulse-labelingshowsthatmostofatemanyofthebiologicalactivitiesofstrandRNAgenome(Mr5.4x106)theE2isincorporatedintovirionsandenvelopedvirions,suchasattachmentofapparentlyactsasmessengerRNArelea
4、sedfromthecellwithin2hoursofviruspeplomers(spikes)toreceptorson(mRNA)forthesynthesisofRNA-synthesis19.AsmallproportionofE2thecellsurface,entryofvirionsintocellsdependentRNApolymerase7.Thiswhichisnotincorporatedintovirionsisbyfusionoftheviralenvelopewithcel-enzymetranscribesthegenome,formingtranspor
5、tedtotheplasmamembranelularmembranes,virus-inducedcellagenome-sized,negative-strandtem-whereitmayparticipateincellfusionfusion,andcellularandhumoralplates.Fromthistemplate,newgenomicandrendercellssusceptibletocell-medi-responsestoviralinfection.InthisbriefRNA,andsixsubgenomicmRNAsareatedcytotoxicit
6、y.Thisrouteforintra-,reviewwewillsummarizerecentstudies,transcribed7,9.Thesecappedandpoly-cellulartransportofE2totheplasmaontheenvelopeglycoproteinsofcoro-adenylatedRNAsallshareacommon3'membraneisthesameasthatofthenaviruses,emphasizingthebiochemicalendandextendfordifferentlengthsinenvelopeglycoprot
7、einsoforthomyxo-,characteristicsassociatedwiththeirdif-the5'direction,formingasetofsevenparamyxo-,rhabdo-andalphaviruses.ferentrolesinintracellularbuddingofoverlappingtranscripts9.RecentstudiesProteolyticcl
