冠状病毒Coronavirusl论文-1968 Virology_ Coronaviruses.pdf

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1、NATURE,VOL.220.NOVEMBER16.1968butnot50ssubunitsist,hesameasinwildt,ypestrains.otherofisoleucineforvaline;inadditionlys-20isInotherwords,itisthe30ssubunitsandothercom-notmethylatedinthepeaprotein.Apartfromthisponentsnecessaryforinitiationandnotthe708astonishingevolu

2、tionaryconservationofsequence-ribosomewhichaffectmRNAsynthesis.aphenomenonaltogetheruniqueamongtheyeryconsiderablenumberofknownsequencesinarangeofGENECONTROLproteinsofthemostdiversefunctions-thisresultpointsineluctablytosomehighlyspecificandpreciselyHistones-Animal

3、andVegetabledefinedbiochemicalfunctionforthehistone.fromourMolecularBiologyCorrespondentTHEbiochemicalworldhaslongbeendividedontheVIROLOGYquestionofwhetherthehistonesareactivelyinvolvedinsuppressionandactivationofgenes,orwhetherthcyexistasessentiallypassive-a

4、reforc,accordingtoANEWgroupofviruseswiththenameofcoronavirusesoneview,slightlydreary-packagingmaterials.AmonghasbeenrecognizedbyaninformalgroupofvirologiststheindicationsthattheroleofthehistonesisnotwhohavesenttheirconclusionstoNature.(Theyarepurelypassivearetheman

5、yobservationsoftheJ.D.Almeida;D.M.Berry;C.H.Cunningham;enzymicmodificationofcertainoftheirsidechainsD.Hamre;M.S.Hofstad;L.Mallucci;K.McIntosh;undercircumstanceswhichsuggestthatthismayD.A.J.Tyrrell.)somehowbeinvolvedinthecontroloftranscriptionTheypointoutthatwithneg

6、ativestaining,avianoftheDNA.TheattachmentofacetylgroupstotheinfectiousbronchitisvirushasacharacteristicelectronN-terminioftwoofthehistones,andofmethylandmicroscopicappearanceresembling,butdistinctfrom,phosphorylgroupstosidechainsofothers,hasbeenthatofmyxoviruses.Pa

7、rticlesaremoreorlessroundeddemonstrated.Allfreyandhisco-workersfoundthatinprofile;althoughthereisacertainamountofpoly-whereassomeofthesemodifyinggroupsremainmoremorphism,thereisalsoacharacteristic"fringe"ofpro-orlesspermanentlybound,othersaremetabolicallyjections20

8、0Along,whichareroundedorpetalshaped,active,inthesensethataradioactiveprecursorisratherthansharporpointed,asinthemyxoviruses.rapidlyincorporatedat