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1、ArchivesofVirology.ArchivesofVirology70,301--313(1981)©bySpringer-Verlag1981HumanEntericCoronav[rusesBriefReviewByM.R.MACNAUGIITONandH.A.DAVI]~SClinicalResearchCentre,WatfordRoad,Harrow,Middlesex,EnglandWith4FignresAcceptedSeptember3,1981IntroductionCoronavirusesareagrou
2、poflipidcontaining,envelopedRNAviruseswithdistinctivesurfaceprojections(44,53,65).Theycauseseriousinfectionsinmanyanimalspecies,includinghepatitisandencephalitisinmice,bronchitisinchickens,encephMomyelitisinpigletsandseveregastroenteritisinneonatalcalves,pigletsanddogs.I
3、ncontrast,allofthemorethan20coronavirusstrainssofarpositivelyisolatedfrommanareinassociationwithmildupperrespiratorytractinfections.Since1975,anumberofreportshaveidentifiedcoronavirus-likeparticles(CVLPs)infaecalspecimensfromadultsandchildrensufferingfromgastro-enteritis
4、andalsofromhealthysubjects:thesehavebeensummarizedpreviously(21,29,40).Similarparticleshavebeenfoundinfaecalsamplesfromanumberofanimals.Inallthesestudies,thepresenceofCVLPswasnotclearlyassociatedwithdiseaseandtheparticleswerecharacterizedascoronavirus-likeentirelyontheir
5、morphology,particularlythepossessionofsurfaceprojectionsapproximately20nmlong.Theparticleswerepleomorphicandusuallymuchlargerthancorona-virusesgrownincellculture.AlthoughmanyattemptshavebeenmadetogrowhumanCVLPsinorganandtissuecultures,allattemptshavefailedwiththeex-cepti
6、onoftwolaboratorieswhichhavereportedtheirgrowtheitherinorgancultures(ll,12)orintissuecultures(35,61),butboththesereportsrequirecon-firmation.Inthisreview,wedescribetheidentificationandclassificationofCVLPsfromfaecalmaterial.Acomparisonismadebetweentheseparticlesandwell-r
7、ecognizedcoronaviruses.TherelationshipofCVLPswithdiseaseandtheapparentgrowthofCVLPsinculturearealsodiscussed.AnewevaluationismadeofavailabledatatoconsiderwhethersomeoranyCVLPsshouldbeclassifiedashumanentericcoronaviruses(HECVs).20Arch,Virol.70/40304-8608/81/0070/0301/$02
8、.60302M.R.MAC~AUG~TOSrandH.A.DAvIEs:MorphologyofC~%PsObtainediromFaecesManyofthereportsoftheoccurrenceo
