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1、AnepigenicswitchcontrolscastebehaviorincarpenterantsantsRESEARCHSimolaetal.,p.42INSCIENCEJOURNALSEditedbyStellaHurtleybeenadoptedforgeneeditingbecauseitcanbedesignedtorecognizeandcutspecificlocationsinthegenome.Achallengeindevelopingclinicalapplicationsisthepotentialforoff-targeteffectsthatcould
2、resultinDNAcleavageatthewronglocations.Slaymakeretal.usedstructure-guidedengineeringtoimprovethespecificityofStreptococcuspyogenesCas9(SpCas9).Theyidentifiedenhanced-specificityvariants(eSpCas9)thatdisplayreducedoff-targetcleavagewhilemaintainingrobuston-onMarch27,2016targetactivityVVScience,thi
3、sissuep.84Polymer-derivedceramiclatticesPROTEINTRANSLOCATIONexhibithighthermalshockresistanceandlowthermalconductivitySeeingthesignalsequenceinactionDownloadedfromProteintranslocationacrossTHREE-DIMENSIONALPRINTINGtheendoplasmicreticulum(ER)Printingceramicsintocomplexshapesinvolvestheinteraction
4、ofasig-nalsequencewiththeproteinomematerials,suchasthermoplasticsandmetals,arenaturallysuitedtobeing3Dprintedtranslocationchannel.Althoughbecausetheindividualparticlescanbefusedtogetherbyapplyingheat.Incontrast,ceram-muchworkhaslookedattheicsdonotfusetogetherthesameway.Eckeletal.developedawaytop
5、atternspecificdetailsofproteintranslocation,preceramicmonomersusingeither3Dprintingorstereolithographyintocomplex,curved,Squestionsremain.Voorheesandandporousshapes.Uponheating,theyobservedalmostnoshrinkage,andtheformedpartsHegdepresentasingle-particleshowedexceptionalthermalstability.—MSLcryoel
6、ectronmicroscopystudyScience,thisissuep.58ofthemammalianERtranslo-cationapparatusatthepointinwhichthesignalsequenceVIROLOGYcamels,Sabiretal.foundthatfortransmissiontohumans,andisengagingthetranslocationCoronavirusesinthedromedariessharethreecoro-conferredcross-immunitytopore.SMHnavirusspecieswit
7、hhumans.camelpoxinfections.CAScience,thisissuep.88MiddleEastDiverseMERSlineagesincamelsScience,thisissuep.81,p.77MiddleEastrespiratorysyn-havecausedhumaninfections,dromecoronavirus(MERS-CoV)whichsuggeststhattransferORGANICCH
