冠状病毒Coronavirusl论文-1992 Enhanced tumor necrosis factor alpha in coronavirus but not in paracetamol-induced acute hepatic necrosis in mice.pdf

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1、Enhancedtumornecrosisfactorabhaincoronavirusbutnotinparacetamol-induced-acutehepatic4.-necrosisin.mce.DevictorD,DecimoD,SebireG,TardieuM,HadchouelM.EnhancedD.Devictor,D.Decimo,G.Seblre,tumornecrosisfactoralphaincoronavirusbutnotinparacetamol-M.TardleuandM.Hadchouelinducedacutehepa

2、ticnecrosisinmice.LaboratoryofNeurovirologyandPediatricHepa-Liver1992;12:205-208.tology,INSERMU56,LeKremlin-BicBtre,FranceAbstract:Previousreportshavedemonstratedthattumornecrosisfactoralpha(TNF-a)playsanimportantroleinthepathogenesisoffulminanthepaticnecrosis.Thepurposeofthisexpe

3、rimentalstudywastomeasureTNF-abloodactivityinparacetamol-inducedlivernecrosisandincor-onavirus(MHV3)-inducedfulminanthepatitisinmice.NoelevationofTNF-aactivitywasfoundinhepaticfailurecomplicatingparacetamolpoisoning.Incontrast,TNF-aactivitysignificantlyincreasedinresponseKeywords:

4、acetaminophen-coronavirus-toMHV3,reaching16.3f5.5U/mlfrom24hpostinfection(P

5、iencesCenter,DivisionofGastroenterologylogicallesionwasobserved.Inconclusion,ourstudyfurthersupportstheCampusBox6158,4200E.NinthAvenue,Den-implicationofTNF-ainvirus-inducedhepatitisfailureandconfirmsver,Colorado.80262USA.thatparacetamolpoisoningdoesnotcauseincreasedTNF-cractivityi

6、nReceived19November1991,acceptedforpubli-thecirculation.cation15May1992PreviousexperimentalandclinicalstudieshaveMaterialandmethodsdemonstratedthatTNF-aisstronglyinvolvedinAnimalsandmaterialthepathogenesisoffulminantlivernecrosis(1,2).IntravenousinjectionofmurinerecombinantSwissmi

7、ce(10-12weeksold)werepurchasedfromTNF-atogalactosamine-sensitizedmiceinducestheCentredeselectionetd’elevaged’animauxdefulminanthepatitis(1).AnincreaseinTNF-apro-laboratoire,Orleans,France.MHV3wasplaque-ductionbybloodmononuclearcellsisfoundinpurifiedinLcellsaspreviouslydescribed(8)

8、.Stockpatientswithfulminanthepati