冠状病毒Coronavirusl论文-1985 Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice.pdf

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1、MedMicrobiollmmunolMedk-(1985)174:15--24lcryandrnunog)gyC)Springer-Verlag1985InfluenceofmaternalimmunityontheoutcomeofmurinecoronavirusJHMinfectioninsucklingmiceK.Pickel*,M.A.Miiller,andV.terMeulenInstituteforVirologyandlmmunobiology,VersbacherStr.7,D-8700Wiirzburg,FederalRepublicofGermanyAbstr

2、act.AdultC3HmiceareresistanttointraperitonealinfectionwithmurinecoronavirusJHM,whereassucklingoffspringofnon-immunefemalesaresuscep-tible.ResistancecanbeconferredonsucklingC3Hmicebypostnataltransmis-sionofmaternalimmunity,iftransferpreceedsinfection.Sucklingmicesuc-cumbtoinfectionevenwhentheyre

3、ceivematernalantibodieswithin1dayafterinfection.Prenataltransmissionalonewithoutsubsequentpostnataltrans-missionofmaternalimmunityisnotsufficienttoprovideresistance.Persis-tenceofviruswithoutclinicalconsequenceswasobservedwhenthesupplyofbreastmilkanti-JHMVantibodieswasterminated5daysbeforeinfec

4、tion.Immunereactionsrestrictedbyhistocompatibilityantigensdonotplayacrucialroleinbestowingresistance.Asneutralizinganti-JHMserumantibodytitersofadultmiceonlyrisesharply5to7daysafterinfection,theseresultsindi-catethatinfectionofadultscanbearrestedbyimmunologicalmeansbutthat,inaddition,therateofv

5、irusdisseminationmustbelimitedbyothernon-immu-nologicalmechanisms.IntroductionTransmissionofpassiveimmunityfrommothertooffspringplaysanimportantroleinneonatallife.Forprotectionagainstinfectionthenewbornanimaldependsheavilyuponthesupplyofmaternalantibody.Inthemouseasmallbutsignificantamountofimm

6、unoglobulinistransmittedinuterotothefetalcirculation,thegreaterpart,however,istransmittedafterbirthviacolostrumandmilk[3].InthepresentstudytheeffectofmaternalimmunityontheoutcomeofintraperitonealinfectionwithmurinecoronavirusstrainJHMinsucklingmicewasinvestigated.JHM-virusisaneurotropicvarianto

7、fmousehepatitisvirus.Intracerebralinjectionofthevirusmayleadtovariousformsofcentralnervoussystemdiseases.Acutediseasealwaysoccurswheneitherintra-peritonealorintracerebralinfectionisshortlyafterbirthandsubacuteorchronicdis-*Corresp