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1、822THELANCET,OCTOBER25,1975CORONAVIRUSANDGASTROENTERITISINation.Thepatients,ofdifferentclassesandnationalities,wereFOALSunanimousinwelcomingthepamphletanddifficultiesoromis•sionswhichtheyraisedweretakenintoaccountinthenextSIR,-Inaneditorial1yousuggestedthatcoronavirusrevision.Working-c
2、lasswomencertainlyunderstooditanddidwasinvolvedinhumangastroenteritis.Welaterreportednotappeartofindanyundueproblems.thatcalf-diarrhceacoronavirusserologicallycross-reactedWithregardtotheassumptionsaboutthebehaviourofwithantibodiesinhumansera.'Theexistenceofanentericfriendsandrelatives
3、,gynaecologistsandobstetricians,inthecoronavirusinmanissupportedbyelectronmicroscopiccourseofclinicalwork,arerepeatedlymadeawareofthefactobservationofsuchparticlesinfrecalspecimensfromanthatpatientsdoreceiveinaccurateandmisleadinginformationoutbreakofhumangastroenteritis.3inthisway.How
4、ever,confirmationwasprovidedbypatientsWeshouldliketoexpandthelistofspeciesinwhichwho,afterreadingitspontaneouslyandspecifically,welcomedcoronavirusmaycausegastroenteritis.Feecalspecimensthepamphlet,amongotherreasons,becauseitavoidedthisfromthreefoalsthatdiedorwerekilledintheacutestageo
5、fparticularproblem.Weshouldaddthatwefoundthatthediseasewereexaminedbyelectronmicroscopy.Allthreepamphletswereborrowedandreadbyotherpatientsinthefoalswerefoundtocontaintypicalcoronavirusparticles.wardandmanyofthoseadmittedforhysterectomyunderThethreespecimensoriginatedfromanendemicareao
6、therfirmscomplainedthattheyhadnotreceivedcopies.WeintheU.S.where40ormorecasesoffoaldiarrhoeahavehaveaccumulatedconsiderableinformationfromourinter•recentlybeenreported.Thediseaseischaracterisedbyviewswhichweintendtopublishandourstudycontinues.profusewaterydiarrheea,fever,extensivelymph
7、aticinvolvement,andahighrateofmortalitydespitetreatment.AcademicDepartmentObstetricsandGyneecology,S.J.STEELEMiddlesexHospitalMedicalSchool,Wehavealsotested65equineseraforserum-neutralisingLondonWIP7PN.M.F.GOODWINantibodyagainstcalf-diarrheeacoronavirus.Titresrangedfromniltogreaterth