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1、953RovalVictoriaInfirmary,Newcastle-upon-Tynefortheircooperationwithfringesabout20nmwide.Nointernalstructurewithhistologicalandhistochemicalanalysisofrectalbiopsyspecimens.wasseeninanyoftheparticles,butsomeshowedRequestsforreprintsshouldbeaddressedtoV.E.
2、B.,FlemingthecollapsedappearancepreviouslyobservedwithB!emona)HospitalforSickChildren,GreatNorthRoad,Newcastle-upon-Tvne,NE23AX.coronaviruses.7TheparticlesdescribedherewereverysimilarinREFERENCESsomeofthosedescribedetappearancetobyMathan1.Bughaighis,A.G.
3、,Emery,J.L.Progr.pædiat.Surg.1971,3,52.al.5infaecesofbothnormalpeopleandpatientswith2.Aaronson,I,Nixon,H.H.Gut,1972,13,138.3.Nixon,H.H.inModernTrendsinSurgery(editedbyW.T.Irvine);p.16.sprueinIndia,includingtheoccasionalbizarre-London,1966.shapedpar
4、ticle.Themorphologyoftheparticlesis4Boston,V.O.E.,Scott,J.E.S.J.pediat.Surg.(inthepress).distinctfromthatoftheoncornaviruses,arenaviruses,5Meier-Ruge,W.,Lutterbeck,P.M.,Herzog,B.,Morger,R.,Moser,R.,Scharli,A.ibid.1972,7,11.andorthomyxoviruses,butidentica
5、lwiththatofthe6Garrett,J.R..Howard,E.R.,Nixon,H.H.ArchsDis.Childh.1969,44,406.coronaviruses.87Ellman.G.,Courtney,KD.,Andres,V.,Featherstone,R.M.Biochem.Phar-mac19607,88.AttemptedPropagation0-05mlofa10%faecalemulsionfrompatientXwasinoculatedintohumanembry
6、ointestinal-organculture.After2days’incubation,thecolumnarCORONAVIRUSPROPAGATEDFROMepitheliumofthevillioftheinoculatedculturescouldPATIENTWITHNON-BACTERIALbeseenmacroscopicallytohavebecomedetached.GASTROENTERITISElectronmicroscopyofthefluidsfromduodenal,
7、jejunal,andilealorganculturesallshowedverylargeE.O.CAULS.K.R.CLARKEnumbersofcoronavirusparticles(fig.lb)similartothoseseeninthefaeces.PublicHealthLaboratory,MyrtleRoad,BristolBS28ELThedetachmentofvillousepitheliumwasthoughttoresultfromthemultiplicationof
8、virus,asitdidnotSummaryAfæcalsuspensionfromapatientwithoccurinuninoculatedcultures,norinthoseinoculatedgastroenteritis,whichcontainedlargewithfaecalsuspensionheatedto56°Cfor30minutes,numbersofcoronavirusparticles
