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1、J.smallAnim.Pract.(1985)26,353-362.Cats,coronavirusesandcoronavirusantibodytestsJ.E.BARLOUGH*CornellFelineHealthCenterandDepartmentofMicrobiology.NewYorkStateCollegeofVeterinaryMedicine,CornellUniversity,Ithaca,NewYork14853.U.S.A.ABSTRACTFelineinfectiousperitonitisandothercorona
2、virusinfectionsofcatsarebrieflyreviewed.Interpretationandapplicationsoffelinecoronavirusantibodytestsaredescribed,andgeneralrecommendationsareprovidedforpractitioners.Someofthemajorunresolvedquestionsregardingcoronavirusinfectionsofcatsaredelineated.INTRODUCTIONThecoronavirusesa
3、realargeandwidelydistributedfamilyofsingle-strandedribonucleicacidviruses,andareimportantcausesofrespiratoryandentericdisease,vasculitis,serositis,hepatitis,andencephalomyelitisinseveralavianandmammalianspecies(Siddelletal.,1983).Felineinfectiousperitonitisvirus(FIPV),transmissi
4、blegastroenteritisvirus(TGEV)ofswine.caninecoronavirus(CCV),andhumanrespiratory-tractcoronavirusesofthe229Egrouptogethercompriseanantigenicclusterofclosely-relatedviruseswithintheCoronaviridaefamily(Pedersen,Ward&Mengeling,1978).Infact,themajorstructuralpolypeptidesofFIPV,TGEV,a
5、ndCCVaresosimilarantigenicallythatsomeregardthesethreeagentsashost-rangemutantsratherthanasindividualviralspecies(Horzinek,Lutz&Pedersen,1982).CORONAVIRUSINFECTIONSOFCATSIndomesticandexoticcats,FIPVistheaetiologicagentofalethaldisease-felineinfectiousperitonitis(FIP)-characteriz
6、edbyfibrinousserositis,vasculitis,andformationofdisseminatedpyogranulomas(Wolfe&Griesemer.1966:Montali&*Presentaddress:CollegeofVeterinaryMedicine,OregonStateUniversity,Corvallis.Oregon97331-4802.U.S.A.0022-4510/85/0600-0353$02.0001985BSVA353354J.E.BARLOUGHStrandberg,1972;Hayash
7、ietal.,1977).Serosalmembranes,liver,kidneys,omentum,lungs,eyes,andcentralnervoussystemarecommonlyaffected.ThepathologyistheresultofcompleximmunologicallymediatedphenomenainvolvingArthus-likeantigen-antibody-complementinteractionsacrossvesselwalls(Jacobse-Geels,Daha&Horzinek,1980
8、,1982;Pedersen&Boyle,1980;Weiss,Dodds&Scott,198
