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《神经节苷脂对重型颅脑损伤患者血清s100b蛋白和nogo―a蛋白水平的影响及疗效观察.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、神经节昔脂对重型颅脑损伤患者血清S100B蛋白和Nogo—A蛋白水平的影响及疗效观察[摘耍]目的探讨神经节苗脂对重型颅脑损伤患者血清S10013蛋白和Nogo-A蛋白水平的影响及疗效观察。方法选择2011年1月〜2013年5月浙江省萧山中医院脑病中心住院的重型颅脑损伤患者74例,将其随机分为观察组和对照组。两组予以控制颅内压、预防感染、营养脑细胞和预防并发症等治疗,有手术指征者行手术治疗。观察组加用神经节昔脂针100mg静滴,1次/d,连用2周。观察两组治疗前后血清S100B蛋白和Nogo-A蛋白水平变化,并比较随访
2、3个月后的临床疗效。结果治疗2周后,两组血清S100B蛋白和Nogo-A蛋白水平[(1.15+0.24).(0.79土0・18)、(181.15±42.87)、(109.16±31.92)ug/L]均较治疗前[(1・59±0・38)、(1.60土0.41)、(218・02±44・12)、(215.81±50.45)ug/L]明显下降(P<0.05或卩〈0.01),且观察组下降值比对照组更明显(卩〈0.05)o治疗后随访3个月,观察组总有效率为86.49%,较对照组的64.86%明显升高(x2二6.19,P<0.05)
3、o结论神经节昔脂治疗重型颅脑损伤具有较好效果,作用机制可能与其能降低血清S100B蛋白和Nogo-A蛋白水平密切相关。[关键词]重型颅脑损伤;神经节昔脂;S100B蛋白;Nogo-A蛋白[中图分类号]R651.15[文献标识码]A[文章编号]1673-7210(2014)02(c)-0059-03InfluenceandcurativeeffectobservationofgangliosideonserumSIOOBproteinandNogo~Aproteinlevelsofpatientswithsevereh
4、eadinjuryYUHuan,dongCAOLiminPEIJingboEncephalopathyCenter,XiaoshanTraditionalChineseMedicineHospital,ZhejiangProvince,Xiaoshan311200,China[Abstract]ObjectiveTodiscussinfluenceandcurativeeffectobservationofGangliosideonserumSIOOBproteinandNogo~Aprotein1evelsofpa
5、tientswithsevereheadinjury.Methods74casesofpatientswithsevereheadinjury,whowereinEncephalopathyCenterofXiaoshanTraditionalChineseMedicineHospitalfromJanuary2011toMay2013weredividedintoobservationgroupandcontrolgroupat.random.Thepatientsintwogroupsweregiventheme
6、dicaltreatmentlikeintracranialpressurecontrol,infectionprotection,braincellsnutrition,compliedtionpreventionandetc.,andthepatientswithoperationindicationsweregiventheoperation.Thepatientsinobservationgroupwereadditionallygiven100mggangliosidebyintravenousinfusi
7、ononceadayfor2weeks.ThechangesofserumSIOOBproteinandNogo~Aprotein1evelsofpatientsintwogroupsbeforeandaftermedicaltreatmentwereobserved,andtheclinicalcurativeeffectafter3months'fol1owing-upwascomparedaswel1.ResuItsAftermedicaltreatmentfor2weeks,serumSIOOBprotein
8、andNogo~Aproteinlevelsofpatientsintwogroups[(1.15±0.24),(0.79±0.18),(181.15±42.87),(109.16+31.92)ug/L]declinedobviouslythanbefore[(1.59±0.38),(1.60±0.41),(21&02土44.12),(215.