神经节苷脂对急性脑梗死患者血清神经元特异性烯醇化酶和s100b蛋白水平的影响及疗效观察.doc

《神经节苷脂对急性脑梗死患者血清神经元特异性烯醇化酶和s100b蛋白水平的影响及疗效观察.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、神经节昔脂对急性脑梗死患者血清神经元特异性烯醇化酉每和S100B蛋白水平的影响及疗效观察［摘要］目的探讨神经节苛脂对急性脑梗死(ACT)患者血清神经元特异性烯醇化酚(NSE)和S100B蛋白水平的影响及疗效观察。方法80例急性脑梗死患者随机分为观察组和对照组。两组均予以降压、降脂、减轻脑水肿等对症治疗。观察组加用神经节昔脂针60嗚静滴，每日1次。对照组加用抱磷胆碱钠针500吨静滴，每H1次，疗程均为2周。结果治疗2周后，两组血清NSE和S100B蛋白水平均明显下降，且观察组比对照组下降更明显；观察组临床总有效率为95.0%,比对照组的80.0%明

2、显上升；对照组和观察组分别发生不良反应3例和5例，症状较轻。结论神经节昔脂治疗急性脑樓死具有良好的疗效，安全性较好，作用与降低血清NSE和S100B蛋白水平密切相关。［关键词］急性脑桢死；神经节昔脂；血清神经元特异性烯醇化酶；S100B蛋口［中图分类号］R743［文献标识码］B［文章编号］1673-9701(2013)34-0066-02Influenceandcurativeeffectobservationofgangliosideonserumneuronspecificenolase(NSE)andSIOOBproteinlevelsof

3、patientswithacutecerebralinfarctionZHANGYuhonglDINGGuojuan21.CadresWard,ShaoxingPeople'sHospitalinZhejiangProvince(ShaoxingHospitalofZhejiangUniversity),Shaoxing312000,China；2.EmergencyDepartment,ShaoxingPeoplesHospitalinZhejiang卩rovinee(ShaoxingHospitalofZhejiangUniversity),

4、Shaoxing312000,China[Abstract]ObjectiveTodiscussinfluenceandcurativeeffectobservationofgangliosideonserumneuronspecificenolase(NSE)andS100Bproteinlevelsofpatientswithacutecerebralinfarction(ACT)•MethodsAtotalof80casesofpatientswithacutecerebralinfarctionweredividedintoobserva

5、tiongroupandcontrolgroupatrandom.Thepatientsintwogroupsweregivensymptomaticandsupportivetreatmentlikebloodpressure-lowering,fatpressure-loweringandcerebraledemaalleviatingandetc.Thepatientsinobservationgroupwasgiven60mggangliosidebyintravenousdriponceaday.Thepatientsincontrol

6、groupwereadditionallygiven500mgsporeciticolinesodiumonceaday.Thecoursesoftreatmentoftwogroupswereboth2weeks.ResultsAfter2weeks'medicaltreatment,serumNSEandSIOOBproteinlevelsandthedecliningofpatientsintwogroupsobviouslydeclined,rate(95.0%)inobservationgroupwasmuchhigherthantha

7、tinthetotalclinicalefficiencycontrolgroup(80.0%)•Meanwhile,ofpatientsinobservationgroupwasmuchhigherthanthatincontrolgroup.3and5casesofuntowardeffectappearedincontrolgroupandobservationgroupduringthemedicaltreatmentwithlightsymptom・Aftercomparingtheoccurrenceratesofuntowardef

8、fect,nostatisticaldifferencesappeared(x2=0.14,卩>0.05).ConclusionGang