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ID:52423279
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页数:8页
时间:2020-03-27
《神经节苷脂对急性脑梗死患者血清神经元特异性烯醇化酶和s100b蛋白水平的影响及疗效观察.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、神经节昔脂对急性脑梗死患者血清神经元特异性烯醇化酉每和S100B蛋白水平的影响及疗效观察[摘要]目的探讨神经节苛脂对急性脑梗死(ACT)患者血清神经元特异性烯醇化酚(NSE)和S100B蛋白水平的影响及疗效观察。方法80例急性脑梗死患者随机分为观察组和对照组。两组均予以降压、降脂、减轻脑水肿等对症治疗。观察组加用神经节昔脂针60嗚静滴,每日1次。对照组加用抱磷胆碱钠针500吨静滴,每H1次,疗程均为2周。结果治疗2周后,两组血清NSE和S100B蛋白水平均明显下降,且观察组比对照组下降更明显;观察组临床总有效率为95.0%,比对照组的80.0%明
2、显上升;对照组和观察组分别发生不良反应3例和5例,症状较轻。结论神经节昔脂治疗急性脑樓死具有良好的疗效,安全性较好,作用与降低血清NSE和S100B蛋白水平密切相关。[关键词]急性脑桢死;神经节昔脂;血清神经元特异性烯醇化酶;S100B蛋口[中图分类号]R743[文献标识码]B[文章编号]1673-9701(2013)34-0066-02Influenceandcurativeeffectobservationofgangliosideonserumneuronspecificenolase(NSE)andSIOOBproteinlevelsof
3、patientswithacutecerebralinfarctionZHANGYuhonglDINGGuojuan21.CadresWard,ShaoxingPeople'sHospitalinZhejiangProvince(ShaoxingHospitalofZhejiangUniversity),Shaoxing312000,China;2.EmergencyDepartment,ShaoxingPeoplesHospitalinZhejiang卩rovinee(ShaoxingHospitalofZhejiangUniversity),
4、Shaoxing312000,China[Abstract]ObjectiveTodiscussinfluenceandcurativeeffectobservationofgangliosideonserumneuronspecificenolase(NSE)andS100Bproteinlevelsofpatientswithacutecerebralinfarction(ACT)•MethodsAtotalof80casesofpatientswithacutecerebralinfarctionweredividedintoobserva
5、tiongroupandcontrolgroupatrandom.Thepatientsintwogroupsweregivensymptomaticandsupportivetreatmentlikebloodpressure-lowering,fatpressure-loweringandcerebraledemaalleviatingandetc.Thepatientsinobservationgroupwasgiven60mggangliosidebyintravenousdriponceaday.Thepatientsincontrol
6、groupwereadditionallygiven500mgsporeciticolinesodiumonceaday.Thecoursesoftreatmentoftwogroupswereboth2weeks.ResultsAfter2weeks'medicaltreatment,serumNSEandSIOOBproteinlevelsandthedecliningofpatientsintwogroupsobviouslydeclined,rate(95.0%)inobservationgroupwasmuchhigherthantha
7、tinthetotalclinicalefficiencycontrolgroup(80.0%)•Meanwhile,ofpatientsinobservationgroupwasmuchhigherthanthatincontrolgroup.3and5casesofuntowardeffectappearedincontrolgroupandobservationgroupduringthemedicaltreatmentwithlightsymptom・Aftercomparingtheoccurrenceratesofuntowardef
8、fect,nostatisticaldifferencesappeared(x2=0.14,卩>0.05).ConclusionGang
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