鼠神经生长因子对急性脑梗死患者血清超敏-C反应蛋白和神经元特异性烯醇化酶水平的影响及疗效观察.pdf

《鼠神经生长因子对急性脑梗死患者血清超敏-C反应蛋白和神经元特异性烯醇化酶水平的影响及疗效观察.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、·临床研究·中国现代医生2014年1月第52卷第2期鼠神经生长因子对急性脑梗死患者血清超敏一c反应蛋白和神经元特异性烯醇化酶水平的影响及疗效观察危英李海军浙江省台州市立医院台州学院医学院附属市立医院神经内二科，浙江台州318000【摘要]目的探讨鼠神经生长因子对急性脑梗死患者血清超敏一C反应蛋白(hs—CRP)和神经元特异性烯醇化酶(NSE)水平的影响及疗效观察。方法72例急性脑梗死患者随机分为观察组和对照组。两组均予以控制颅内压、血压和血糖、抗血小板聚集、保护脑细胞及防治并发症等治疗。观察组患者加用鼠神经生长因子18g肌肉注射，1次／d，连

2、用2周。结果治疗2周后，两组患者血清hs—CRP和NSE水平均有明显下降(P0．05)。结论鼠神经生长因子治疗急性脑梗死具有较好的疗效及安全性，能明显改善

3、患者的神经功能及肢体运动功能，作用与其能降低血清Nhs—CRP和NSE水平密切相关。f关键词】急性脑梗死；鼠神经生长因子；超敏一c反应蛋白；神经元特异性烯醇化酶【中图分类号】R743【文献标识码】B[文章编号】1673—9701(2014)02—0030—03Theinfluenceandcurativeefectofmousenervegrowthfactoronhigh-sensitivityC-reactiveprotein(hs—CI)andneuron-specificenolasefNSE)inbloodserumofacutec

4、erebralinfarctionpatientsWElYingLIHaijunNo．2DepartmentofNerve，TaizhouMunicipalHospital，Zhejiang(TheAffiliatedMunicipalHospitalofTaizhouMed—icalCollege)，Taizhou318000，China[Abstract]ObjectiveTodiscusstheinfluenceandcurativeeffectofmousenervegrowthfactoronhigh——sensitivityC——

5、reactiveprotein(hs——CRP)andneuron-specificenolase(NSE)inbloodserumofacutecerebralinfarctionpatients．Methods72casesofacutecerebralinfarctionpatientsweredividedintoobservationgroupandcontrolgroup．Allpatientsweregivensymptomaticandsupportivetreatmentroutinelylike，intracranialp

6、ressurecontrol，bloodpressureandbloodsugarcontrol，plateletaggregation，braincellsprotection，preventionandtreatmentofcomplications，andetc．Thepatientsinobservationgroupweregivenmousenervegrowthfactor(18g)byintramuscularinjectiononetimedailyfor2weeks．ResultsAfter2weeks’medicaltr

7、eatment，theserumhs-CRPandNSElevelsofpatientsintwogroupsobviouslyweredeclinedthanbefore(P<0．05orP<0．01)，andthedecliningrateofobservationgroupwasmuchhigherthanthatincontrolgroup(尸<0．05)．Meanwhile，NHSSscoresofpatientsintwogroupsweredeclinedobviouslythanbefore(：0．05orP<0．01)，wh

8、iletheFMAscoreswereroseobviouslythanbefore(P<0．05orP<0．01)，anddeclin—ing／risingrat