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1、不同剂量阿托伐他汀短期治疗急性冠脉综合征对炎症因子影响探究【中图分类号】R543.3【文献标识码】A【文章编号】1005-2720（2009）09-0273-04【摘要】目的：评价他汀类药物治疗急性急性冠脉综合征对炎症因子的影响，进一步探讨急性冠脉综合征患者应用他汀类药物的必要性和有效性。方法：选取诊断为ACS住院患者92例，入选者全部接受ACS常规治疗，同时发病48h内按就诊时间和随机数字表分为：A组（阿托伐他汀10mg组）30例，除基础和对症治疗外给予阿托伐他汀10mg/d,立即服用，以后每
2、晚睡前服用；B组（阿托伐他汀40mg组）31例，基础治疗外给予阿托伐他汀40mg/d立即服用，以后每晚睡前服用；C组（对照组）31例，仅给予预基础和对症治疗,未给予阿托伐他汀治疗，服药持续时间为2w。药物治疗前及治疗后3h、6h、24h、48h、72h、lw和2w抽取空腹静脉血,待测血清炎症因子、血清脂质和肝功能等相关指标。结果：①B组治疗后3d时IL-6.CRP、TNF-a浓度明显低于治疗前和A、C组同期检测结果（P均0.05）o结论：ACS早期应用阿托伐他汀即有明显的抗炎和调脂作用，且以大剂
3、量组疗效更明显。【关键词】白细胞介素；C-反应蛋白；肿瘤坏死因子;阿托伐他汀；急性冠脉综合征Theeffectsofdifferentdoseofatorvastatinoftheshort-termtherapyoninflammationfactorsinpatientswithacutecoronaryarterysyndrome・LuJie.(ShenzhouhospitalofShenyangmedicalcollege,Liaoning110002,China)[AbstTact】O
4、bjective：ToevaluatetheeffectionofstatinoninflamnidtionfactorinACS,andprobeintothenecessarityandeffectivityofstatininACS・Methods：Selecting92casesfromthepatientsinhospitaldiagnosisedtobeACS.AlltheselectedCandidatesaccepttheACSroutinetreatment，andaccord
5、ingtothetimeofseeingadocrorandthestochastictablesdividedthemwithin48hfromoverbreaking:GroupA(atorvastatinlOmg)30cases,givingatorvastatinexceptforroutinetreatment1Omg/d,tobetakenatonce，thenbeforebedtimeeverynight；GroupB(atorvastatin40mg)31cases,giving
6、atorvastatinexceptforroutinetreatment40mg/d,tobetakenatonce,thenbeforebedtimeeverynight；GroupC(contractgroup)31casesthesametotheothertwogroupexceptfornotgivingatorvastatin，thetimeofdrugintakinglasted2weeks・Seruminflammdtionfactors,serumlipidandhepati
7、cfunctionweretestedbeforeand3h,6h,24h,48h,72h,lw,2waftertest.Results：①AftrethetreatmentofGroupB,in3days,theserumIL~6,CRP,TNF-adensitywerelowerthanbeforetreatedandthedeterminationresultsofGroupAandCinthecorrespondingtimeperiodobviously(PavO.05)・Conclu
8、sion：Atorvastatinnamelytohavetheexplicitanti—infectionandthefatfunctionintheACSearlytimeapplication,thebigmonitoringteamcurtiveeffectsaremoreobvious・[KeyWords]1nterleukin；C~reactiveprotein；Tumornecrosisifactor；Atorvastatin；Acutecoronaryarterysyndrome
