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时间:2020-02-29
《无症状高尿酸血症与急性脑梗死相关性的研究分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、·76·吉林医学2017年1月第38卷第1期无症状高尿酸血症与急性脑梗死相关性的研究分析周志全,黄颖妍,宋海锋,李书剑,黄登鹏(广东省连州市人民医院内科二区,广东连州513400)[摘要]目的:探讨无症状高尿酸血症与急性脑梗死之间的关系。方法:选择急性脑梗死患者108例为试验组,选择同期住院患者或门诊健康体检者105例为对照组,测定血尿酸水平。试验组按(NIHSS)卒中量表对所有患者的神经功能缺损程度进行评分,分成轻度组、中度组、重度组3个亚组;另按血尿酸水平分成血尿酸正常组和高尿酸血症组;治疗第10~1
2、4天再次对神经功能进行评分,评价疗效。结果:①脑梗死组血尿酸水平均高于对照组(P<0.01);②脑梗死患者病情严重程度与血尿酸水平呈正相关,重度组血尿酸水平高于中度组、轻度组及对照组(P<0.01),中度组高于轻度组、对照组(P<0.01),轻度组高于对照组(P<0.01);③脑梗死患者血尿酸水平正常组治疗有效率>高尿酸血症组(P<0.05)。结论:无症状高尿酸血症与急性脑梗死的发生密切相关,是其独立的危险因素,尿酸水平高低与病情呈正相关,且尿酸水平是预测疗效的重要指标。[关键词]脑梗死;高尿酸血症;无症
3、状;危险因素ResearchandAnalysisofCorrelationbetweenAsymptomaticHyperuricemiaandAcuteCerebralIn-farctionZHOUZhi-quan,HUANGYing-yan,SONGHai-feng,etal(Section2ofInternalMedicine,ThePeople'sHos-pitalofLianzhou,Guangdong,Lianzhou513400,China)Abstract:ObjectiveToinve
4、stigatetherelationshipbetweenasymptomatichyperuricemiaandacutecerebralinfarc-tion.Method108casesofacutecerebralinfarctionpatientswereselectedasthetreatmentgroup,105inpatientsorhealthypeo-pletookphysicalexaminationatthesameperiodweretakenasthecontrolgroup,
5、andblooduricacidlevelofeachobjectinthetwogroupswastested.Forthetreatmentgroup,degreeofnervousfunctionaldefectswerescoredtoeachpatientaccordingtoNIH-SSandclassifiedintothreesubgroups,i.e.mildteam,mediumteamandsevereteam;andthenthetreatmentgrouppatientswere
6、alsodividedintonormalteamandhighlevelteamaccordingtotheirblooduricacidlevels;10~14daysafterthetreatmentwasimplemented,degreeofnervousfunctionaldefectswerescoredagaintoassessthecurativeeffect.Results①theaveragebloodu-ricacidlevelofcerebralinfarctiongroupwa
7、shigherthanthatofcontrolgroup(P<0.01);②thediseaseseverityofcerebralin-farctionpatientswaspositivelyrelatedtoblooduricacidlevel,assevereteamhadhigherblooduricacidlevelthanmildteamandmediumteam(P<0.01),mediumteamholdshigherblooduricacidlevelthanmildteamandc
8、ontrolgroup(P<0.01),andmildgrouphadhigherblooduricacidlevelthancontrolgroup(P<0.01);③forcerebralinfarctionpatients,theeffectiverateoftreatmentinnormalteam(blooduricacidlevel)washigherthanthatinhighlevelteam(P<0.05).
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