别嘌呤醇治疗急性脑梗死伴高尿酸血症的临床效果.pdf

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1、窑临床药学窑中国当代医药2015年5月第22卷第14期别嘌呤醇治疗急性脑梗死伴高尿酸血症的临床效果郭建军倪晓俊史丽刘就娣吴小燕魏伟民广东省增城市人民医院神经内科袁广东增城511300[摘要]目的探讨别嘌呤醇治疗急性脑梗死伴高尿酸血症的临床效果遥方法选取2013年10月耀2014年10月本院收治的80例急性脑梗死伴高尿酸血症患者作为研究对象袁随机分为对照组和观察组袁各40例遥对照组给予抗凝尧抗血小板聚集等对症治疗袁观察组在对照组的基础上给予别嘌呤醇袁比较两组治疗前后的血清尿酸水平尧神经功能缺损评分以及临床效果遥结果两组治疗后的血清尿酸水平与神经功能缺损评分显著低于治疗前

2、袁差异有统计学意义渊P约0.05冤遥观察组治疗后的血清尿酸水平与神经功能缺损评分显著低于对照组治疗后袁差异有统计学意义渊P约0.05冤遥观察组的总有效率为92.5%袁显著高于对照组的75.0%袁差异有统计学意义渊P约0.05冤遥结论别嘌呤醇能够明显降低急性脑梗死伴高尿酸血症患者的血清尿酸水平袁改善患者的神经功能缺损症状袁值得临床推广应用遥[关键词]别嘌呤醇曰高尿酸血症曰急性脑梗死曰疗效[中图分类号]R743.3[文献标识码]A[文章编号]1674-4721渊2015冤05渊b冤-0114-03Clinicaleffectofallopurinolinthetreatm

3、entofacutecerebralinfarctioncombinedwithhyperuricemiaGUOJian-junNIXiao-junSHILiLIUJiu-diWUXiao-yanWEIWei-minDepartmentofNeurology,People忆sHospitalofZengchengCityinGuangdongProvince,Zengcheng511300,China[Abstract]ObjectiveToexploretheclinicaleffectofallopurinolinthetreatmentofacutecerebr

4、alinfarctioncombinedwithhyperuricemia.Methods80patientswithacutecerebralinfarctioncombinedwithhyperuricemiafromOctober2013toOctober2014inourhospitalwereselectedandrandomlydividedintothecontrolgroupandtheobservationgroup,40casesineachgroup.Thecontrolgroupwasgivensymptomatictreatmentlikea

5、nticoagulantandanti-plateletaggregation,theobservationgroupwastreatedwithallopurinolonthebasisofthecontrolgroup.Thelevelofserumuricacid,thescoreofneurologicalfunctiondefectandclinicaleffectbeforeandaftertreatmentintwogroupswascompared.ResultsThelevelofserumuricacidandthescoreofneurologi

6、calfunctiondefectintwogroupsaftertreatmentwaslowerthanthatbeforetreatment,withsignificantdifference(P约0.05).Thelevelofserumuricacidandthescoreofneuro鄄logicalfunctiondefectintheobservationgroupaftertreatmentwaslowerthanthatinthecontrolgroupaftertreatment,withsignificantdifference(P约0.05)

7、.Thetotaleffectiverateintheobservationgroupwas92.5%,whichwashigherthan75.0%inthecontrolgroup,withsignificantdifference(P约0.05).ConclusionAllopurinolcansignificantlyreduceserumuricacidlevelandimprovesymptomsofneurologicalfunctiondefectinpatientswithacutecerebralinfarctioncom鄄bin