四联药物联合治疗慢性胃炎的疗效观察 优先出版.pdf

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1、·368·ChineseJournalofNewClinicalMedicine，April2017，Volume10，Number4学术交流四联药物联合治疗慢性胃炎的疗效观察余天奉作者单位:511458广东，广州市南沙区鱼窝头医院内科作者简介:余天奉(1978－)，男，大学本科，学士学位，主治医师，研究方向:内科疾病的诊治。E-mail:yutianfeng2007@163．com［摘要］目的探讨四联药物联合治疗慢性胃炎的疗效。方法选取2014-02～2016-02收治的64例慢性胃炎患者作为

2、研究对象，随机分为对照组和观察组各32例。分别给予单一药物(阿莫西林)和四联药物(阿莫西林、呋喃唑酮、奥美拉唑、胶态果胶铋)治疗，对比两组患者临床疗效和不良反应发生率。结果观察组显效14例，有效15例，无效3例;对照组显效8例，有效13例，无效11例，观察组疗效优于对照组(P＜0.05)。观察组不良反应发生率(6.25%)明显低于对照组(25.00%)(P＜0.05)。结论阿莫西林、呋喃唑酮、奥美拉唑、胶态果胶铋四联药物联合治疗慢性胃炎，具有疗程短、剂量小、不良反应发生率低等优点，临床疗效显著，

3、值得推广应用。［关键词］阿莫西林;呋喃唑酮;奥美拉唑;胶态果胶铋;慢性胃炎［中图分类号］Ｒ573［文献标识码］B［文章编号］1674－3806(2017)04－0368－03doi:10．3969/j．issn．1674－3806．2017．04．23TheeffectsofquadrupledrugtherapyonchronicgastritisYUTian-feng．DepartmentofInternalMedicine，theYuwotouHospitalofNanshaDistric

4、t，GuangzhouCity，Guangdong511458，China［Abstract］ObjectiveToevaluatetheeffectsofdrugtherapyonchronicgastritis．MethodsSixty-fourpa-tientswithchronicgastritistreatedinourhospitalfromFebruary2014toFebruary2016wereselectedastheresearchsubjectsandwererandom

5、lydividedintothecontrolgroupandtheobservationgroup，with32casesineachgroup．Thecontrolgroupwasgivensingledrugamoxicillinandtheobservationgroupwasgivenquadrupledrugtherapyincludingamoxicillin，furazolidone，omeprazoleandcolloidalbismuthpectin．Theclinicale

6、fficacyandincidenceofadversere-actionswerecomparedbetweenthetwogroups．ＲesultsTheefficiencyoftheobservationgroupwasmarkedlyeffec-tivein14cases，effectivein15casesandinvalidin3cases;Theefficiencyofthecontrolgroupwasmarkedlyeffec-tivein8cases，effectivein

7、13casesandinvalidin11cases．Thetotaleffectiverateoftheobservationgroupwassig-nificantlyhigherthanthatofthecontrolgroup(P＜0.05);Theincidenceofadversereactionsintheobservationgroupwassignificantlylowerthanthatinthecontrolgroup(6.25%vs25.00%)(P＜0.05)．Con

8、clusionThequadrupledrugtherapyiseffectiveonchronicgastritis，withashortercourseoftreatment，asmallerdosage，lowerpriceandalowerincidenceofadversereactions．［Keywords］Amoxicillin;Furazolidone;Omeprazole;Colloidalbismuthpectin;Chronicgastritis慢性胃炎(chronicg