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1、ResearchProgressoftheSuzukiCouplingReactionAbstractSuzukicouplingreactionisoneofthemostimportantapproachesforC-Cbonds"constructionandalwaysahighlightonorganicandcatalyticchemistry.Inthispaper;therecentprogressofSuzukicouplingreactionisreviewed・WedrawattentionontheprinciplesofSuzukicouplin
2、greactionandtheSuzukicouplingreactioncatalyzedbyPd,Ni,Cuandothercatalysts.KeywordsSuzukicouplingreactioncatalystsprinciple1.IntroductionSuzukicouplingreactionmeansthereactionofalkylhalides,arylhalidesoralkenylhalideswithorganicboronicreagentsonconditionofPdcatalyzing.Generalreactionequati
3、onisfollowing./PdR-X+R[—BaR~RiBaseRX=alkenyl,aryl,alkenylhalidesRx=alkyl,arylSuzukireactionpossessestheadvantagesofmildreactionconditions,goodchemicalselectivityandstereoselectivity,andthereactionmediumisnon-toxic,etc.Thereactionhasbeengeneratedinoneofthemostimportantorganicreactionabout
4、thecarbon・carbonbondcouplingreaction.2.TheprincipleofSuzukicouplingreactionCatalyticcycleoftheSuzukicouplingreactionisgenerallyconsideredthatPd(O)firstoccursoxidation-additionreactionwithhalogenatedaromatichydrocarbon,generatingacomplexofPd(ll),thenthemetaltransferreactionoccurs,producing
5、acomplexofPd(ll),andfinallyreductiorneliminationreactionhappens,obtainingtheproductandPd(0).Aliprrantisetal.haveverifiedthecyclebyexperiments.Theydetectedfragmentions([(Pyr)Pd(PPh3)2Br]+and[(Pyr)(R1R2C6H3)Pd(PPh3)2]+)intheSuzukicouplingreactionof3一bromopyridineandphenyIboronicacidbyESI-MS
6、,reactionequationisReetzandHyeonputforwardadifferentviewthatactivesitemaybenanoscalepalladiumcolloidorshell・3.ResearchProgressoftheSuzukireactionThecatalystsofTheSuzukicouplingreactioniscommonlyconstitutedbyPdsourcesandligands.PalladiumsourcesaretypicallyPdCI2,Pd(OAc)2orPd2(dba)3etc.Accor
7、dingtothediffereneeofthecoordinatingatomsoftheligands,theligandscanbedividedintoseveralparts,single-phosphineligand,bisphosphineligands,P-Nligand,N-Nligandsandsoon.2.1Palladium-catalyzedSuzukicouplingreactionMaJ.T.etal.preparedapalladium-basedcatalystsupportedonamin
