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1、ResearchinVeterinaryScience93(2012)88–96ContentslistsavailableatSciVerseScienceDirectResearchinVeterinarySciencejournalhomepage:www.elsevier.com/locate/rvscUrinaryglycosaminoglycansinhorseosteoarthritis.Effectsofchondroitinsulfateandglucosamineb,⇑bbaRaquelY.A.Baccarin,ThaísS.L.Machado,AnaP.Lopes-Mo
2、raes,FabianaA.C.Vieira,aYaraM.MichelacciaDepartamentodeBioquímica,EscolaPaulistadeMedicina,UniversidadeFederaldeSãoPaulo,UNIFESP,SãoPaulo,SP,BrazilbDepartamentodeClínicaMédica,FaculdadedeMedicinaVeterináriaeZootecnia,UniversidadedeSãoPaulo,USP,SãoPaulo,SP,BrazilarticleinfoabstractArticlehistory:Our
3、objectivesweretocharacterizetheurinaryexcretionofglycosaminoglycans(GAGs)inhorseosteo-Received13May2011arthritis,andtoinvestigatetheeffectsofchondroitinsulfate(CS)andglucosamine(GlcN)uponthedis-Accepted19August2011ease.UrinaryGAGsweremeasuredin47athletichorses,20healthyand27withosteoarthritis.Theef
4、fectsofCSandGlcNwereinvestigatedinmildosteoarthritis.Incomparisontonormal,urinaryGAGswereincreasedinosteoarthritis,includingmildosteoarthritisaffectingonlyonejoint.TreatmentwithKeywords:CS+GlcNledtoalonglastingincreaseintheurinaryCSandkeratansulfate(KS),andsignificantimprove-Chondroitinsulfatementin
5、flexiontestoftarsocruralandmetacarpophalangealjointswasobserved.Inconclusion,urinaryGlucosamineCSandKSseemstoreflecttheturnoverratesofcartilagematrixproteoglycans,andthemeasurementofUrinaryglycosaminoglycanHorsethesecompoundscouldprovideobjectivemeansofevaluatingandmonitoringjointdiseases.Keratansulf
6、ateÓ2011ElsevierLtd.Allrightsreserved.Osteoarthritis1.Introductiontinsulfate(CS)andkeratansulfate(KS),whichoccurinthetissueasproteoglycans.Thereareevidencesindicatingthatmostoftheuri-Osteoarthritis(OA)isachronicconditioncharacterizedbypro-naryGAGsareofsystemicorigin:CSisthemainurinaryandplas-gressi
7、vedegenerationofarticularcartilageaccompaniedbysclero-maticGAGinmanymammalianspecies,butitisnotpresentsisofthesubchondralbone(Reginster,2002).Clinicalfeatureseitherintheurinarytract(Pereiraetal.,2004;deLima
