脂肪肝的病理与临床研究

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1、脂肪肝的病理与临床研究【关键词】脂肪肝［摘要】H的研究脂肪肝的临床特点，提高脂肪肝的早期临床诊断的止确性。方法对50例经肝活检确诊为轻■中度脂肪肝的患者的临床资料中的症状、体征、检验、特检加以分析总结，统计学方法采用t检验，x2检验。结果50例脂肪肝患者,年龄17〜46岁;男46例，女4例;肥胖者26例,占52%;酗酒者6例，占12%;血脂升高者10例,占20%;无症状者22例,占44%;疲乏、纳差、肝区隐痛者25例，占50%。病理改变:以大泡性川•细胞脂肪变性为主，偶见点、灶状坏死，伴轻度纤维组织增牛，少数町见Mollory小体及炎性细

2、胞浸润。肝损害的程度与肝细胞脂肪变性的程度相关，但统计学无差异;血脂的高低与脂肪肝的程度无关(PX).05)°B超无典型改变者22例，占44%;脂肪肝中度肝静脉变细声像明显多于轻度(P<0.05)o结论脂肪肝发病年龄偏小，男性，肥胖，血脂不高者多;临床衣现轻微，病程隐匿，50%B超呈典型改变;肝活检是早期诊断脂肪肝的手段。关键词脂肪肝临床超声波检查肝脏病理vPstyle="TEXT-INDENT:24px"align=center>Pathologyandclinicoffattyliver

3、xHalign=center>ZhangChunlan,FanHuimin,YiJunqingThe8thPeople*sHospitalofGuangzhouCity,Guangzhou510060.［Abstract］ObjectiveTounderstandtheclinicalcharactersofearlyfattyliverandincreasetheearlycorrectdiagnosisoffattyliver.Methods50casesw

4、ithmildandmiddlefattyliverdiagnosedbylivebiopsywerestudiedandtheirinformationwasanalyzedbystatisticalmethodsuchastesttandx2.ResultsTheagesofpatientswithfattyliverwereamong17to46years;themalecasesofthemwere46,thefemalewere4;thefatwere26(accountfor52%);thealcoholicwere6(12%);thehightributyrinandchole

5、sterolwere10(20%);theasymptomaticwere22(44%);thesymptomaticwithfatigue,anorexiaandabdominaldiscomfortwere25(50%)・Pathologicalobservation:thelargevac一uolesteatosisofhepatocyteswasthemostprominentincentri-lobularcells,occasionallyspottyorfocalnecrosisofhepatocytesandslightfibrosisproliferationoccurre

6、d,littlewithMollorybodiesandinflammatoryinfiltrationofpolymor'phonuclearleukocytes.Theliverinjurieddegreesseemedtoberelatedtohepatocytessteatosisdegreesbuttherewasnodifferenceinstatisticbetweenthem(P>0.05);thehightributyrinandcholesterolvalueswerenotrelatedtohepa~tocytessteatosisdegrees(P>0.05).The

7、patientswithnotypicalultrasonogramoftypeBwere22(occupied44%);the1iverveinsofpatientswithmiddlefattyliveronultrasonogrambecamesmallerwhichweremorethanthosewithmildfattyliver(P<0.05)・ConclusionThepatientswith