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时间:2019-11-25
《低度恶性子宫内膜间质肉瘤临床病理特征及误诊原因探析_仰晨》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·1568·仰晨低度恶性子宫内膜间质肉瘤临床病理特征及误诊原因探析?妇科肿瘤?低度恶性子宫内膜间质肉瘤临床病理特征及误诊原因探析仰晨Themisdiagnosisandclinicopathologicfeaturesanalysisoflow-gradeendometrialstro-malsarcomaYangChenDepartmentofGynecology,AffiliatedHospitalofNanjingTraditionalChineseMedicineUniversity(JiangsuProvinceHospi
2、talofTCM),JiangsuNanjing210029,China.【Abstract】Objective:Toinvestigatetheclinicalandpathologicalfeaturesoflow-gradeendometrialstromalsar-coma(LGESS),toimprovetherateofthediagnosisofLGESS,determinetheoperablerange,avoidthesecond-opera-tion.Methods:TwocasesofLGESSwereana
3、lyzedbymeansofreviewingthehistoryrecordsfromApril,2010toApril2011inourhospitalandconnectingthecorrelativereport.Results:ThemainclinicalsymptomsofLGESSwereirregu-larvaginalbleeding,hypomenorrheaorpostmenopausal,hypogastricpain,andoccasionallytouchingamass.Thetumorcellre
4、sembledtheendometrialstromalcellofproliferationphaseonHEstaining.Therewerealotofbloodvesselsjustlikethespiralinthetumors.TwocaseswerepositiveforCD10,ERandPRbyimmunohistochemicalfindings.Conclu-sion:LGESSisveryrareandeasytomisdiagnosis,thediagnosisreliesmainlyonhistopat
5、hologicalandimmunohisto-chemicalfindings.TheprognosisofLGESSisbetter.Itisnecessaryofdiagnosticcurettagebeforeoperating.Inoperat-ingifwedoubtsarcoma,wemustrapiddohistopathologicalexamination.Thecurativeeffectofannexectomyandchemicaltherapyisbetter.【Keywords】endometrials
6、tromalsarcoma;clinicopathologicfeatures;misdiagnosisModernOncology2015,23(11):1568-1570【摘要】目的:探讨低度恶性子宫内膜间质肉瘤(LGESS)的临床病理特征,提高LGESS早期诊断率,以确定手术范围,避免二次手术。方法:对2010年4月至2011年4月我院收治的2例LGESS病例临床及病理资料进行回顾性分析,结合相关文献报道。结果:低度恶性子宫内膜间质肉瘤临床表现为阴道不规则出血,月经过多或绝经后阴道流血、下腹痛,偶尔触及包块。HE染色见肿瘤细胞
7、类似增生期子宫内膜间质细胞,螺旋小血管多见,免疫组化染色2例患者肿瘤细胞CD10、Vimentin、ER、PR均(+)。结论:低度恶性子宫内膜间质肉瘤临床少见,易误诊,确诊主要依靠组织病理学和免疫组织化学。本病预后较好,术前诊断性刮宫是必要的,术中疑有恶性应送快速冰冻病理检查,采用全子宫及双附件切除,辅以化疗者疗效更好。【关键词】子宫内膜间质肉瘤;临床病理特征;误诊【中图分类号】R737.33【文献标识码】ADOI:10.3969/j.issn.1672-4992.2015.11.28【文章编号】1672-4992-(2015)11
8、-1568-03低度恶性子宫内膜间质肉瘤(low-gradeendometrial1临床资料stromalsarcoma,LGESS)是子宫肉瘤的一种,来自子宫内膜间我院自2010年4月至2011年4月收治2例低度恶性子质细胞,临床较
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