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1、妊娠合并甲状腺功能亢进37例临床研究【中图分类号】R714.256【文献标识码】A【文章编号】1005-2720(2009)08-0290-03【摘要】目的:探讨甲状腺功能亢进症(甲亢)患者妊娠期治疗是否能减少妊娠并发症及改善母婴结局。方法:回顾分析2006年1月〜2008年8月3年间在我院分娩的37例妊娠合并甲亢患者妊娠期治疗及母婴结局。37例患者分二组:病情控制满意组(A组):24例患者,在孕前或孕中诊断、系统治疗,病情控制满意,分娩时甲状腺功能正常。病情控制不满意组(B组):13例患者,孕前或孕中诊断甲亢,孕期未
2、系统治疗或就诊晚,病情重,终止妊娠时甲状腺功能仍明显异常。结果:妊娠合并甲亢进入围产期的发病率为2.74%o(37/13516),B组与A组相比,重度子痫前期(23.1%和12.5%)、胎膜早破(23.0%和12.5%)、羊水异常(8.3%和0%)、早产(69.2%和8.3%)、低体重儿(61.5%和4.2%)、新生儿畸形(15.4%和0%)、围产儿死亡(15.4%和0%)的发生率明显增加。结论:甲亢的孕前和孕期治疗、积极控制病情,可有效降低孕期并发症,改善围产期母儿结局。【关键词】甲状腺功能亢进症;母儿并发症;妊娠结
3、局Theclinicalanalysison37gravidaswhowerehyperthyreosis・QuZhenhua,GuoXiaoling,FanLian,ZhouXing.(ThematernalandchildhealthcarehospitalofFoshan,Guangdong528000China)[AbstractlObjective:Toinvestigatetheinfluencesofthetreatmentonhyperthyroidismduringgestationalperiod・
4、Methods:AnalyzedthetreatmentandtheoutcomeofperipartumofpregnancycomplicatedhyperthyroidismretrospectivelyduringJanuary2006toAugust2008.Therewere37patientswhowerediagnosedashyperthyroidismintheperiodofprogestationordurationofpregnancyweredividedtotwogroups,groupA
5、andgroupB.GroupAwhowereconsistof24patientsweretreatedsysteniatically,meanwhile,groupBwhowereconsistof13patientswasnot.ThecontrolationonpathogeneticconditionofgroupAwassatisfaction,andeuthyroidismwasnormalwhendelivery,whengroupBwasopposite・Results:Theincideneerat
6、eofpregnancycomplicatedhyperthyroidisminperiparturnis2.74%oinperipartum.ThecomparisonofgroupBandgroupA,theincidencesofsevereeclampsism(23・1%and12.5%),prematureruptureofmembrane(23・0%and12.5%),abnormityofamnioticfluid(8.3%and0%),prematurity(69.2%and8.3%),lowbirth
7、weightinfant(61.5%and4.2%),neonatemalformation(15.4%and0%),thedeathofperinataichild(15.4%and0%)wereincreasingobviously.Conclusion:Thetreatmentonhyperthyroidismintheperiodofprogestationanddurationofpregnancy,andthecontrolingonpathogeneticconditionactivly,couldred
8、ucecomplicationofgestationandimprovetheoutcomeofperipartum.[KeyWords]Hyperthyroidism;Gestationalperiodcomplication;Pregnancyfate甲状腺功能亢进症,是妊娠期第二位最常见的内分泌疾病,发病率仅次于糖尿病。妊娠