同步放化疗治疗局部晚期鼻咽癌疗效观察

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1、同步放化疗治疗局部晚期鼻咽癌疗效观察【摘要】目的探讨同步放化疗治疗晚期鼻咽癌的疗效以及患者接受治疗后的耐受性。方法75例局部晚期鼻咽癌患者随即分为两组，放化疗组37例和单纯放疗组38例。放化疗组采用放疗同步顺钳加氯尿喀噪化疗，观察两组的临床疗效以及患者的不良反应情况。结果放化疗组总有效率是78.3%（29例），单纯放疗组总有效率是63.1%（24例），两者的差异具有统计学意义（P〈0.05）。放化疗组3年生存率是59.4%（22例），单纯放疗组3年生存率是39.4%（15例）,两者的差异同样具有统计学意义（P〈0.05）。放化疗组的患者不良反应高于单纯

2、放疗组，但经过对症处理后患者均可耐受。结论同步放化疗可以提高晚期鼻咽癌患者的局部控制率和生存率，患者可以耐受不良反应，值得临床推广应用。【关键词】同步放化疗；单纯放疗；晚期鼻咽癌；耐受性doi：10.3969/j.issn.1004-7484（x）.2012.08.059文章编号：1004-7484（2012）-08-2458-02ClinicalobservationofConcurrentchemoradiotherapytreatmentoflocallyadvancednasopharyngealcarcinomaFENGYa-lin,LIUW

3、ei-mingThefirstChinesepeople，sLiberationArmyeightonehospital(Guilin)oncology,GuangxiGuilin541002【Abstract】ObjectiveToinvestigatethesynchronousradiotherapyandchemotherapytheefficacyofthetreatmentofadvancednasopharyngealcarcinomapatientsaftertreatmenttolerability・Methods75patients

4、withlocallyadvancednasopharyngealcarcinomapatientswererandomlydividedintotwogroups,radiotherapyandchemotherapygroupof37casesand38casesradiotherapyalonegroup・RadiotherapyandchemotherapygroupweretreatedwithradiotherapySynchronouscisplatinchlorinationuracilchemotherapy,andobserveth

5、eclinicalefficacyofthetwogroupsofpatientswithadversereactions・ResuItRadiotherapyandchemotherapygroup,thetotalefficiencyis78.3%(29cases),radiotherapyalonegroup,thetotalefficiencyis63.1%(24cases),bothstatisticallysignificantdifferenee(P〈0.05)・Chemoradiotherapygroup3-yearsurvivalis

6、59.4%(22cases),radiotherapyalonegroup3-yearsurvivalwas39.4%(15cases),thediffereneeisalsostatisticallysignificant(P〈0.05).Patientswithadversereactionstoradiotherapyandchemotherapygroupthantheradiotherapyalonegroup,butafterthepatientsinthesymptomatictreatmentcouldbetolerated.Concl

7、usionConcurrentchemoradiotherapycanimprovelocalcontrolandsurvivalratesofpatientswithadvancednasopharyngealcareinoma,thepatientcantolerateadversereactions,isworthyofclinicalapplication.【Keywords】Concurrentchemoradiotherapy；Radiotherapyalone；Advancednasopharyngealcarcinoma；Toleran

8、ce在我国，鼻咽癌是最多见的头颈部恶性肿瘤之一。但是,它和其它头颈部肿瘤又有着明显的区别，鼻咽