[精品]窄谱红蓝光联合克痤隐酮凝胶治疗炎症性痤疮疗效观察

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1、窄谱红蓝光联合克瘗隐酮凝胶治疗炎症性瘗疮疗效观察窄谱红蓝光联合克痙隐酗凝胶治疗炎症性痙疮疗效观察［摘要］目的:评价窄谱红蓝光与克痙隐酮凝胶联合治疗炎症性痙疮的疗效。方法:选择中重度(Pillsbury分级为II或III度)寻常型座疮患者214例，分为试验组(98例)和对照组(116例)。试验组采用窄谱红蓝光与克痙隐酮凝胶联合治疗，对照组单用克痊隐酮凝胶治疗。结果:试验组患者痊愈率为28.57%,有效率为83.67%,对照组患者痊愈率为10.34%,有效率为50.86%,两组在痊愈率及有效率上均有显著性差异(P〈0.05)。结论:窄谱红蓝光联合克痊隐酮凝胶治疗炎症性痙疮疗效好、不良反

2、应小，在疗效方面明显优于单用克座隐酮凝胶治疗。［关键词］寻常型座疮;炎症;红蓝光；克痊隐酮凝胶［中图分类号］R622［文献标识码］A［文章编号］1008-6455(2010)02-0235-03Observationontheclinicalefficacyofblue-redLEDphototherapyandKecuoyintonggelcombinationintheTtreatmentofacnevulgariswithinflaminationYUZhi-ming,CAILi-min,LiuJing,WANGYan-hua,ZHENGShu-yun,ZHANGXiu-yi

3、ng,TIANJing,SHENGYu(DepartmentofDermatology,theFirstAffiliatedHospitalofHarbinMedialUniversity,Harbin150001,China)Abstract:0bjectiveToevaluatetheclinicalefficacyofblue-redLEDphototherapyandKecuoyintonggelcombinationinthetreatmentofacnevulgariswithinflammation.Methods214patientswithmediumorseve

4、redegreeofacnevulgaris(PillsburygradeIIorIII)weredividedintotwogroups:thetestgroup(98patients)andthecontrolgroup(116patients)・Blue-RedLEDphototherapyplusdailyexternaluseofKecuoyintonggelweregiveninthetestgroup・Others,thecontrolgroupweretreatedwithonlydailyexternaluseofKecuoyintonggel.After4wee

5、ks,thetherapeuticefficacyanalysiswastakenfollowingcompletionofthetherapy.ResultsThecurativerateandtheeffectiverateinthetestgroupwas28.57%and83.67%,however,10.34%and50.86%inthecontrolgroup.Therewasastatisticallysignificantdifferenceinthecurativerateandtheeffectiveratebetweentwogroups（P<0・05）.Co

6、nclusionThecombinativetherapyofblue-redLEDphototherapyandKecuoyintonggelismoreeffectivethanKecuoyintonggelonlyinthetreatmentofacnevulgariswithinflammation.Keywords:acnevulgaris;inflammation;Blue-RedLEDphototherapy;Kecuoyintonggel寻常型座疮是皮肤科常见的…种毛囊皮脂腺慢性炎症性疾病，病因复杂涉及多种因素。座疮丙酸杆菌过度繁殖被认为是引起瘁疮炎症反应发生及加重

7、的重要因素。以往对以炎症反应为主的座疮治疗，主要以口服及外用抗生素类及维A酸类等抗炎药物为主，中医主要以清泄肺胃、疏肝滋阴等方法进行调理，往往需要治疗吋间长、副作用较大，疗效不佳[1-2]o近年来光学疗法的发展为炎症性座疮的治疗开辟了新途径，应用波长为415nn）的蓝光结合波长为633nm的红光治疗座疮，可使座疮丙酸杆菌产纶的内源性光敏物质被激活产牛单态氧，从而导致细菌死亡，同时红光可以最大限度地减少与座疮有关的红斑反应，减少瘢痕的形成[3]o2008年9月〜2009