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1、胰腺实性假乳头状瘤临床病理分析作者：周莉,屈重筲'，亢姝娇单位：泰山医学院附属聊城市第二人民医院，山东临清252600;山西省人民医院，山西太原030012;赤峰市中心医院，内蒙古赤峰024000【摘要】目的：探讨胰腺实性一•假乳头状瘤(SPTP)的临床病理学及免疫纽•化特点。方法：4例SPTP作HE、免疫组织化学((PV2000法)染色观察。结果：4例SPT中3例为女性，1例男性，年龄15岁〜36岁，平均年龄27岁，术后均无复发。肿瘤体积较人，平均直径8.6cm,有包膜，囊实性相间。镜检，肿瘤由乳头和囊实区混合组成，细胞
2、形态一•致，核圆或卵圆，显型不明显，核分裂彖罕见。瘤细胞围绕纤维血管轴心形成特征性假乳头结构。1例侵犯胰腺周围组织。多数肿瘤表达vimentin,a-AT,a-ACT,部分表达Syn,CgA,PR和AE1/AE3,EMA,ER均阴性。结论：胰腺SPTP好发年轻女性，具有独特的临床病理特点，手术切除治愈率高，应视为低度恶性肿瘤，免疫组化提示可能起源于胰腺多能干细胞。【关键词】胰腺肿瘤；免疫组织化学；预后SolidPseudopapillaryTumorofthePancreasAclinicopathologicAnalys
3、isof4CasesZhOULi,QUChong-xiao,KANGShu-jiao(TheSecondPeople'sHospitalofTaishanMedicalCollegeinLiaocheng,Linqing.Shandong,252600,China;ThePeople'sHospitalofShanxi,Taiyuan,Shanxi,030012,China;TheCentralHospitalofChifeng,Chifeng,Neimenggu,024000,China)Abstract：Objecti
4、veTostudytheclinicopathologicandimmunohistochemicalcharacteristicsofsolidpseudopapillaryneoplasmofpancreas(SPTP).Methods4casesofSPTPwerestudiedbyusinghistologicHEandimmunohistochemistry(PV2000method).ResultsTherewere3femaleand1malepatientsagedfrom15to36(meanage27)
5、inourcasesthathadnorecurrenceafterresection.Thosetumorswerelargerinsize(meandiameterof8.6cm),solidalternatelywithcysticandcircumscribedbycapsule.Histologically,theywerecomposedofpapillaryandmicrocysticsolidstructures,withuniformedpopulationofcells,Thenuclearwereov
6、abroundwithoutatypia,andratemitoticfigures・Pseudopapillawithfibrovascularcorewasremarkable・Infiltralingintothepancreaticparenchymawereseenin1cases.Immunohistochemistry,Mostcasesexpressedvimentin,a-AT,a-ACTJesscasesexpressedSyn,CgA.PRandAE1/AE3,butallcaseswerenegat
7、iveforER,EMA・ConclusionSPTPofthepancreas,preferentiallytoyoungwomen,areuncommontumors.Thereareadistinctclinicopathologicentityand,thoughahighcureratebysurgicalresection,itisatumoroflowgrademalignant.ImmunohistochemicalstudiessuggestedthattheoriginofSPTistotipotent
8、ialprimordialcellsfoundinthedevelopmentoftheembryonicpancreas・Keywords：Pancreaticneoplasmsimmunohistochemistry;Prognosis肌腺实性假乳头状瘤(Solid-PseudopapillaryT
