“从肝论治，理气调神”针刺法治疗过敏性鼻炎的实验研究

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1、“从肝论治，理气调神”针刺法治疗过敏性鼻炎的实验研究耿国燕I,王朋2,张佳佳2,王蓬文3,任映3,赵吉平2(1.北京中医药大学针灸推拿学院，北京100029；2.北京屮医药大学东直门医院针灸科，北京100700；3.北京中医药大学东直门医院中心实验室，北京100700)摘要：H的：探讨“从肝论治，理气调神''治疗AR的有效性及作用机制方法：将40只豚鼠雌雄各半，随机分为5组，分別为1空白组、2模型组、3西药组、4常规组、5疏肝组，每组8只，雄鼠、雌鼠各4只。第2•第5组以OVA复制AR模型。造模成功后次日开始干预:空口组、模型组不

2、干预；西药组双侧鼻孔喷布地奈德喷雾剂，每次、每侧鼻孔1喷(64ug)；常规组针刺双侧迎香、肺俞穴；疏肝针刺组针刺双侧迎香、肺俞、肝俞、太冲穴。肺俞、肝俞均不留针，余穴留针20分钟。第3■第5组均每日干预1次，共干预15次。末次干预后给予10%水合氯醛麻醉，然后在腹主动脉取血，经相应处理后，进行血清SP(ELISA)测定及鼻粘膜嗜酸性粒细胞(EOS)计数。结果：西药疗法、常规针刺法及疏肝针刺法均能有效改善AR症状，抑制SP的群放，且三组疗效相当(p>0.05)；在改善鼻粘膜嗜酸性粒细胞(EOS)浸润方面，疏肝针刺法优于西药疗法和常规

3、针刺法，差异显著(p<0.05)o结论：“从肝论治，理气调神''针法能通过抑制SP的释放，减轻EOS浸润释放，达到减轻AR症状，治疗AR的目的。关键词：针灸；过敏性鼻炎；调神；豚鼠中图分类号：R245ArandomizedcontrolledexperimentofsoothingliverandregulatingmindacupunctureGENGGuoyam,WANGPeng2,ZHANGJiajia?,WANGPengwem,RENYings,ZHAOJiping?(1.Acupuncture&moxibustionan

4、dTuinaSchool,BeijingTraditionalChineseMedicineUniversity,Beijing100029;2.AcupuclureandMoxibustionDepartment,DongzhimenHospital,Beijing100700;3.Centrallaboratory,DongzhimenHospital,Beijing100700)Abstract:Inthispaper,thcrcYctwoobjects.Firstistoexplorewhetherthemethodofs

5、moothingliverandregulatingmindacupunctureisscientific,andtheeffectivenessofthistreatmentforAR.SecondistoexplorethemechanismandtargetsofacupuncturetreatmentonAR,accordingtoexperimentalresearchMethod:40guineapigs(20males,20females)wererandomlydividedintofivegroups,Group

6、1blankgroup.2modelgroup,3westernmedicinegroup),4regulargroup,5smoothinglivergroup,n=&4males,4化males.Group2-5copytheARmodelbyOVA・Interventionswascarried,afterthe10thintranasalsensitization:blankgroup,modelgroupofnon-intervention;westernmedicinegroupweresprayedbudesonid

7、esprays,eachnostrilsspray(64ug);regulargroupwereacupuncturedbilateralYingxiang(L120)andFeishu(BL13);smoothinglivergroupwereacupuncturedbilateralYingxiang(LI20),Feishu(BL13),Ganshu(BL18)andTaichong(LR3).(L120),Feishu(BL13)andGanshu(BL18)werewithoutkeepingtheneedles,the

8、needlewerekeptfor20minutesinL120andLR3.Interventionsforgroup3-5wereperformedonceadayfor15times・Onthedayofthe15thintervention