MAPK信号途径大综述

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1、BiochimicaetBiophysicaActa1773(2007)1311–1340www.elsevier.com/locate/bbamcrReviewFunctionandregulationinMAPKsignalingpathways:LessonslearnedfromtheyeastSaccharomycescerevisiaeRaymondE.Chen,JeremyThorner⁎DivisionofBiochemistryandMolecularBiology,DepartmentofMolecularandCellBio

2、logy,UniversityofCalifornia,Berkeley,CA94720-3202,USAReceived19February2007;receivedinrevisedform2May2007;accepted4May2007Availableonline22May2007AbstractSignalingpathwaysthatactivatedifferentmitogen-activatedproteinkinases(MAPKs)elicitmanyoftheresponsesthatareevokedincellsby

3、changesincertainenvironmentalconditionsanduponexposuretoavarietyofhormonalandotherstimuli.ThesepathwayswerefirstelucidatedintheunicellulareukaryoteSaccharomycescerevisiae(buddingyeast).StudiesofMAPKpathwaysinthisorganismcontinuetobeespeciallyinformativeinrevealingthemolecular

4、mechanismsbywhichMAPKcascadesoperate,propagatesignals,modulatecellularprocesses,andarecontrolledbyregulatoryfactorsbothinternaltoandexternaltothepathways.HerewehighlightrecentadvancesandnewinsightsaboutMAPK-basedsignalingthathavebeenmadethroughstudiesinyeast,whichprovidelesso

5、nsdirectlyapplicableto,andthatenhanceourunderstandingof,MAPK-mediatedsignalinginmammaliancells.©2007ElsevierB.V.Allrightsreserved.Keywords:Mitogen_activatedproteinkinase;MAPK;Fus3;Kss1;Hog1;Mpk1/Slt2;Smk1;Mitogen_activatedproteinkinasekinase;MAPKK;Ste7;Pbs2;Mkk1;Mkk2;Mitogen_

6、activatedproteinkinasekinasekinase;MAPKKK;Ste11;Ssk2;Ssk22;Bck1;Mitogen_activatedproteinkinasekinasekinasekinase;MAPKKKK;Pkc1;p21_activatedproteinkinase;PAK;Ste20;5′_AMP_activatedproteinkinase;AMPK;Snf1;3′,5′_cyclicAMP_dependentproteinkinase;PKA;Tpk1;Tpk2;Tpk3;Pheromonerespon

7、se;Filamentousgrowthresponse;Hyperosmoticstressresponse;Cellwallintegrity;Signaling;Meiosisandsporulation;Signaltransductionmechanisms;Signalpropagation;Signalingfidelity;Spatialandtemporalregulation;Yeast;Saccharomycescerevisiae;Baker'syeast;Buddingyeast1.Introductionthisorg

8、anismandarenowknowntohavebeenconservedduringtheevolutionoftheentiree